BDCA3(+)CLEC9A(+) human dendritic cell function and development.
BDCA3(+)CLEC9A(+) human dendritic cell function and development.
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DOI：
10.1016/j.semcdb.2014.05.016
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发表时间：
2015-05
影响因子：
7.3
通讯作者：
E. van der Aa;Nadine van Montfoort;A. Woltman
中科院分区：
文献类型：
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作者：
E. van der Aa;Nadine van Montfoort;A. Woltman
树突状细胞（DC）是最强的抗原提呈细胞（APC）。它们包括一个不同亚群的家族，在诱导和调节免疫应答中发挥重要作用。最近，基因表达谱鉴定BDCA3+CLEC9A+DC为单独的人DC亚群。该亚群在血液中鉴定，其中它们代表人DC的最小群体，以及在淋巴和外周组织中。本文综述了BDCA 3 +CLEC9A+DC与其小鼠等同物CD 8 α+DC和CD 103 +DC及其他人DC亚群的表型、功能和发育特征。除了是有效的抗原呈递细胞之外，与其他人DC亚群相比，它们的特化功能能力表明这些BDCA 3 +CLEC9A+DC在诱导抗病毒和抗肿瘤免疫中是非常重要的。进一步表征它们的功能特性、发育途径和潜在的分子机制可以鉴定靶分子以充分利用BDCA 3 +CLEC9A+DC的免疫调节功能以及这些细胞在免疫治疗中的潜在用途。
Dendritic cells (DC) are the most potent antigen presenting cells (APC). They comprise a family of different subsets and play an essential role in the induction and regulation of immune responses. Recently, gene expression profiling identified BDCA3+CLEC9A+DC as a separate human DC subset. This subset was identified in blood, where they represent the smallest population of human DC, as well as in lymphoid and peripheral tissues. This review summarizes the phenotypic, functional and developmental characteristics of BDCA3+CLEC9A+DC in relation to their mouse equivalents CD8α+DC and CD103+DC and other human DC subsets. Apart from being potent antigen presenting cells, their specialized functional capacities compared to other human DC subsets, indicate that these BDCA3+CLEC9A+DC are of major importance in the induction of anti-viral and anti-tumor immunity. Further characterization of their functional properties, developmental pathways and underlying molecular mechanisms may identify target molecules to fully exploit the immune modulatory function of BDCA3+CLEC9A+DC and potential use of these cells in immunotherapy.