Regional Variations and Intra-/Intersession Repeatability for Scotopic Sensitivity in Normal Controls and Patients With Inherited Retinal Degenerations
Regional Variations and Intra-/Intersession Repeatability for Scotopic Sensitivity in Normal Controls and Patients With Inherited Retinal Degenerations
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DOI：
10.1167/iovs.18-25473
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发表时间：
2019-03-01
影响因子：
4.4
通讯作者：
Birch, David G.
中科院分区：
文献类型：
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作者：
Bennett, Lea D.;Metz, Georgiana;Birch, David G.
目的.从遗传性视网膜变性（IRD）患者和对照组中获得暗适应视野，以评估年龄、视网膜区域和疾病对暗视敏感性的影响。测量患者和对照组的期内和期间重测重复性，以建立纵向研究的显著变化。共有41名IRD患者和30名对照者的一只眼睛扩张并暗适应了40分钟。使用Medmont暗适应色（DAC）视野计（大小为V的刺激，持续时间为200 ms，背景亮度< 0.0001 cd/m（2），动态范围0-75分贝[dB]）测量暗视敏感度。进行混合效应分析以分析年龄、视网膜偏心率和敏感性。计算对照组和IRD患者的重复性（CR）的会话内/会话间系数。与年轻对照组（12-49岁）相比，50岁以上的正常对照组每年的敏感度（-0.22 dB）每增加一年。正常对照组中，上级视野的敏感性低于低级视野，但鼻侧视野与颞侧视野相比无差异。对于IRD患者，平均灵敏度（MS）/逐点灵敏度（PWS）的会话内和会话间测试的CR分别为+/- 1.5/+/- 8.5和+/- 3.3/+/- 9.8 dB。对照MS/PWS CR在会话内为+/- 1.5/+/- 6.1 dB，会话间DAC周长为+/- 1.7/+/- 6.8 dB。DAC视野计是一项重要的资产，因为它可以测试广泛的暗视觉视野。CR与其他视野检查器械相当。当用DAC视野计测量暗视敏感度时，应考虑年龄和视网膜区域的影响。
PURPOSE. Dark-adapted visual fields were obtained from patients with inherited retinal degeneration (IRD) and controls to evaluate the effect that age, retinal region, and disease had on scotopic sensitivity. Intra-and intersession test-retest repeatabilities for patients and controls were measured to establish significant change for longitudinal studies.METHODS. A total of 41 patients with IRD and 30 controls had one eye dilated and dark-adapted for 40 minutes. Scotopic sensitivity was measured with a Medmont dark-adapted chromatic (DAC) perimeter (size V stimulus, 200-ms duration, background luminance < 0.0001 cd/m(2), dynamic range 0-75 decibel [dB]). Mixed effects analysis was performed to analyze age, retinal eccentricity, and sensitivity. The intra-/intersession coefficients of repeatability (CR) were calculated for controls and patients with IRD.RESULTS. Each additional year was associated with lower sensitivity (-0.22 dB) per year in normal controls over age 50 compared to younger controls (12-49 years). The superior field had lower sensitivity than the inferior, but the nasal field was not different compared to the temporal field in normal controls. The CR for intra-and intersession testing on mean sensitivity (MS)/pointwise sensitivity (PWS) were +/- 1.5/+/- 8.5 and +/- 3.3/+/- 9.8 dB, respectively, for patients with IRD. Control MS/PWS CR were +/- 1.5/+/- 6.1 dB for intrasession and +/- 1.7/+/- 6.8 dB for intersession DAC perimetry.CONCLUSIONS. The DAC perimeter is an important asset because it tests a wide field of scotopic vision. The CR are comparable to those of other perimetry devices. Effects of age and retinal region should be considered when assessing scotopic sensitivity measured with the DAC perimeter.