ASSIMILATION OF CHOLESTEROL BY LACTOBACILLUS-ACIDOPHILUS
ASSIMILATION OF CHOLESTEROL BY LACTOBACILLUS-ACIDOPHILUS
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DOI：
10.1128/aem.49.2.377-381.1985
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发表时间：
1985-01-01
影响因子：
4.4
通讯作者：
MAXWELL, C
中科院分区：
文献类型：
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作者：
GILLILAND, SE;NELSON, CR;MAXWELL, C
不同菌株间存在较大差异。从猪的粪便植物群中分离的嗜酸乳杆菌，具有在胆汁存在下良好生长和从实验室生长培养基中吸收胆固醇的能力。只有当培养物在无氧条件下在胆汁存在的情况下生长时，才会发生胆固醇的吸收。消费L。嗜酸乳杆菌RP 32，其选择的能力，在胆汁的存在下生长良好，并从实验室培养基中同化胆固醇，显着抑制高胆固醇饮食的猪血清胆固醇水平的增加（P < 0.05）。消费L。嗜酸乳杆菌P47，其被选择为具有在胆汁存在下生长的能力和缺乏从生长培养基中除去胆固醇的能力，不能具有类似的效果。L.嗜酸乳杆菌可直接作用于胃肠道中的胆固醇，并可有益于降低血清胆固醇水平。
Considerable variation was found among strains of L. acidophilus isolated from the fecal flora of pigs with regard to the ability to grow well in the presence of bile and to assimilate cholesterol from a laboratory growth medium. The uptake of cholesterol occurred only when the culture(s) was growing in the presence of bile under anaerobic conditions. Consumption of L. acidophilus RP32, which was selected for its ability to grow well in the presence of bile and to assimilate cholesterol from the laboratory medium, significantly inhibited increases in serum cholesterol levels of pigs (P < 0.05) fed a high-cholesterol diet. Consumption of L. acidophilus P47, which was selected for its ability to grow in the presence of bile and lack of ability to remove cholesterol from the growth medium, failed to have a similar effect. Certain strains of L. acidophilus may act directly on cholesterol in the gastrointestinal tract and may be beneficial in reducing serum cholesterol levels.