: Feedback mechanism for microtubule length regulation by bistable stathmin gradients
: Feedback mechanism for microtubule length regulation by bistable stathmin gradients
复制标题
：双稳态 Stathmin 梯度调节微管长度的反馈机制
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通讯作者：
Jan Kierfeld
中科院分区：
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作者：
Maria Zeitz;Jan Kierfeld
辅助材料包含聚合微管反馈系统、局部 Rac1 和胞质 stathmin 的模拟方法的详细信息。我们还提出了关于 stathmin 激活梯度的附加模型方程和模拟结果。我们展示了没有 Rac 和组成型活性 stathmin 的中断反馈子系统的其他结果。对于具有闭合反馈的完整系统，我们提供了理论分岔分析的详细信息。最后，我们提出了关于我们的结果相对于灾难模型和系统长度的变化的稳健性的额外结果。
The Supporting Material contains details of the simulation methods for the feedback sys-tem of polymerizing microtubules, localized Rac1 and cytosolic stathmin. We also present additional model equations and simulation results on the stathmin activation gradient. We show additional results on the interrupted feedback subsystem without Rac and constitutively active stathmin. For the full system with closed feedback, we present details of the theoretical bifurcation analysis. Finally, we present additional results on the robustness of our results with respect to changes in the catastrophe model and the system length.