Linear basal cell carcinoma: Report of seventeen cases and review of the presentation and treatment
Linear basal cell carcinoma: Report of seventeen cases and review of the presentation and treatment
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DOI：
10.1046/j.1524-4725.1999.08104.x
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发表时间：
1999-01-01
影响因子：
2.4
通讯作者：
Marcil, I
中科院分区：
文献类型：
--
作者：
Lim, KK;Randle, HW;Marcil, I
背景资料。1985年，线形基底细胞癌首次被描述为一种独特的临床形态变异。方法：对梅奥诊所和蒙特利尔大学三个校区收治的原发基底细胞癌和文献中的12例进行回顾性分析。结果：共确诊17例线性基底细胞癌。年龄和性别比例与标准基底细胞癌患者相似。基于对少数报道的线性基底细胞癌病例的回顾(29例)，与普通人群相比，侵袭性组织学亚型的百分比(38%)有所增加。治疗所需的平均Mohs层数高于报道的标准基底细胞癌，这表明亚临床扩散增加。结论：线性基底细胞癌是一种罕见的形态变异。在少数病例的基础上，这些肿瘤具有更具侵袭性的组织亚型。由于亚临床扩散的可能性增加，可以考虑进行莫氏显微外科手术治疗。需要进一步的研究来证实这些发现。
BACKGROUND. Linear basal cell carcinoma was first described as a distinct clinical morphologic variant in 1985. Subsequently, twelve cases were reported.OBJECTIVE. To review and identify cases of linear basal cell carcinoma in our institutions and determine optimal treatment based on review of our cases and those in the literature.METHODS. Primary basal cell carcinomas treated at the three campuses of Mayo Clinic and the University of Montreal were reviewed retrospectively, as were the twelve cases in the literature.RESULTS. Seventeen cases of linear basal cell carcinoma were identified. The age and sex ratios were similar to those of patients with standard basal cell carcinomas. Based on the review of the few reported cases of linear basal cell carcinoma (29), the percentage of aggressive histologic subtypes (38%) was increased compared with that in a general population. The average number of Mohs layers required for treatment was higher than that reported for standard basal cell carcinoma, an indication of increased subclinical spread.CONCLUSION. Linear basal cell carcinoma is an uncommonly recognized morphologic variant. Based on the small number of cases, these tumors have more aggressive histologic subtypes. Because of the possibility for increased subclinical spread, Mohs micrographic surgery can be considered for treatment. Further studies are needed to confirm these findings.