Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity
Development of a computational fluid dynamics model for mucociliary clearance in the nasal cavity
复制标题
鼻腔粘液纤毛清除计算流体动力学模型的开发
DOI：
10.1016/j.jbiomech.2019.01.015
复制
发表时间：
2019-03-06
影响因子：
2.4
通讯作者：
Tu, Jiyuan
中科院分区：
文献类型：
--
作者：
Shang, Yidan;Inthavong, Kiao;Tu, Jiyuan
鼻内给药引起了极大的关注，因为有机会将全身药物直接输送到血液中。然而，由于纤毛不断地将黏液带向喉区，因此纤毛黏液清除对获得高效鼻内给药带来了挑战。为了更好地理解黏液在人类鼻腔壁上的流动行为，我们提出了计算模型的开发，并在ct扫描重建的真实鼻腔模型上评估黏液运动。模型开发涉及基于实际鼻腔几何形状的两种方法，即：(i) 2D域的未包裹表面模型和（ii） 3d壳模型。将流体运动守恒方程应用于该域，其中粘液产生源项用于启动粘液运动。分析包括黏液流动模式、虚拟糖精测试和定量速度大小分析，结果表明3d壳模型结果与实验数据吻合较好。与实验数据相比，未包裹表面模型在展开阶段也遭受网格变形，这导致了更高的黏液速度。因此，3D-shell模型被推荐用于未来的粘液流动模拟。作为建立黏液运动模型的第一步，本研究提供了准确模拟人类鼻腔壁上黏液速度场的重要信息，用于评估鼻内给药的毒理学和疗效。爱思唯尔2019年版权所有版权所有。
Intranasal drug delivery has attracted significant attention because of the opportunity to deliver systemic drugs directly to the blood stream. However, the mucociliary clearance poses a challenge in gaining high efficacy of intranasal drug delivery because cilia continuously carry the mucus blanket towards the laryngeal region. To better understand mucus flow behaviour on the human nasal cavity wall, we present computational model development, and evaluation of mucus motion on a realistic nasal cavity model reconstructed from CT-scans. The model development involved two approaches based on the actual nasal cavity geometry namely: (i) unwrapped-surface model in 2D domain and (ii) 3D-shell model. Conservation equations of fluid motion were applied to the domains, where a mucus production source term was used to initiate the mucus motion. The analysis included mucus flow patterns, virtual saccharin tests and quantitative velocity magnitude analysis, which demonstrated that the 3D-shell model results provided better agreement with experimental data. The unwrapped-surface model also suffered from mesh-deformations during the unwrapping stage and this led to higher mucus velocity compared to experimental data. Therefore, the 3D-shell model was recommended for future mucus flow simulations. As a first step towards mucus motion modelling this study provides important information that accurately simulates a mucus velocity field on a human nasal cavity wall, for assessment of toxicology and efficacy of intranasal drug delivery. Crown Copyright (C) 2019 Published by Elsevier Ltd. All rights reserved.