Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers
Effect of oral carbohydrate with amino acid solution on serum oxidative/anti-oxidative status in healthy volunteers
复制标题
口服碳水化合物与氨基酸溶液对健康志愿者血清氧化/抗氧化状态的影响
DOI：
10.1007/s00540-017-2355-x
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发表时间：
2017
期刊：
影响因子：
2.8
通讯作者：
and Katsuya Tanaka.
中科院分区：
文献类型：
--
作者：
Yasuo M. Tsutsumi;Takuro Oyama;Nami Kakuta;Yousuke T. Horikawa;Katsuyoshi Kume;Yoko Sakai;Rie Tsutsumi;and Katsuya Tanaka.
本研究旨在探讨含氨基酸的口服碳水化合物[口服营养补充剂（ONS）]溶液对正常人氧化应激的影响。14名健康志愿者被分为对照组和非离子组。ONS组志愿者在实验前一天晚上和实验当天早上7点分别摄入精氨酸水250 ml（日本雀巢公司，东京，日本）。对照组志愿者在晚餐后禁食，只喝水，直到实验当天早上7点。两组患者均于上午9点采血。采用d-ROMs（活性氧代谢物衍生物）试验和BAP（生物抗氧化潜能）试验分别评价血清总氧化剂水平和抗氧化能力。ONS组血清d-ROMs水平显著低于对照组（分别为297±43 μ mol/l和327±41 μ mol/l， p= 0.018），血清BAP水平显著高于对照组（分别为2410±432和1979±397 μ mol/l， p= 0.005）。精氨酸水的氧含量远高于术前饮料（Nutricia, Ireland）。综上所述，我们的研究表明，负载精氨酸的ONS可以降低健康志愿者的氧化应激，提高抗氧化能力。
The aim of this work was to investigate the effect of oral carbohydrate with amino acid [oral nutritional supplement (ONS)] solution on oxidative stress in healthy persons. Fourteen healthy volunteers were segregated into control and ONS groups. Volunteers in the ONS group ingested 250 ml of Arginaid Water (Nestle Japan, Tokyo, Japan) in the evening before the experiment and at 7:00 am on the day of the experiment. Volunteers in the control group fasted after dinner and drank only water until 7:00 am on the day of the experiment. In both groups, blood was collected at 9:00 am. The serum total oxidant levels and antioxidant capacity were assessed by d-ROMs (derivatives of reactive oxygen metabolites) test and BAP (biological antioxidant potential) test, respectively. In the ONS group, the serum d-ROMs level was significantly lower than in the control group (297 ± 43 and 327 ± 41 U.CARR, respectively,p= 0.018), while the serum BAP level was significantly higher than the control group (2410 ± 432 and 1979 ± 397 µmol/l, respectively,p= 0.005). The OXY level of Arginaid Water was much higher than preOp drink (Nutricia, Ireland). In conclusion, our study showed that an ONS with arginine loading could decrease oxidative stress and increase antioxidant capacity in healthy volunteers.