Are 'healthy cohorts' real-world relevant? Comparing the National Child Development Study (NCDS) with the ONS Longitudinal Study (LS)
Are 'healthy cohorts' real-world relevant? Comparing the National Child Development Study (NCDS) with the ONS Longitudinal Study (LS)
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DOI：
10.1332/175795920x15786630201754
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发表时间：
2020-07-01
影响因子：
0.9
通讯作者：
Shelton, Nicola
中科院分区：
文献类型：
--
作者：
Archer, Gemma;Xun, Wei W.;Shelton, Nicola
队列研究与具有全国代表性的“真实世界”样本之间的比较是有限的。 NCDS（1958 年英国出生队列）追踪 1958 年 3 月单周内在英国出生的人（n=18,558）； ONS 纵向研究 (LS) 包含英格兰和威尔士 1% 人口样本的相关人口普查数据和生活事件（> 100 万条记录；允许按年龄、种族或其他社会人口因素进行子样本）。常见的国家和年龄匹配的社会人口变量是从最接近的对应时间点、2013 年 NCDS 55 年调查 (n=8107) 和 2011 年 55 岁 LS 受访者 (n=7052) 中提取的。使用逻辑回归评估社会人口暴露（来自 2004 年 NCDS 46 调查和 2001 年 45 岁 LS 受访者）与长期限制性疾病（来自 NCDS 2013 和 2011 年 LS 受访者，55 岁）之间的纵向关联。 NCDS 55 岁样本在性别和婚姻状况方面与 55 岁 LS 受访者具有相似的特征，但 NCDS 样本的长期限制性疾病水平较低（19.7% vs 22.8%）、非白人种族（2.1% vs 11.7%）和居住在英格兰南部（46.9% vs 50.1%），并且全职就业水平较高（61.2% vs 50.1%）。 55.2%），从事专业/高级管理职业（35.7% vs 29.2%），与配偶同居（69.1% vs 64.9%），全部p0.09）表明这些 NCDS 调查结果在很大程度上适用于英格兰和威尔士人口。
Comparisons between cohort studies and nationally representative 'real-world' samples are limited. The NCDS (1958 British birth cohort) follows those born in Britain in a single week in March 1958 (n=18,558); and the ONS Longitudinal Study (LS) contains linked census data and life events for a 1% sample of the population of England and Wales (> 1 million records; allowing for sub-samples by age, ethnicity, or other socio-demographic factors). Common country-and age-matched socio-demographic variables were extracted from the closest corresponding time-points, NCDS 55-year survey in 2013 (n=8107) and LS respondents aged 55 in 2011 (n=7052). Longitudinal associations between socio-demographic exposures (from the NCDS 46-survey in 2004 and LS respondents aged 45 in 2001) and long-term limiting illness (from NCDS 2013 and LS respondents 2011, aged 55) were assessed using logistic regression. The NCDS 55-year sample had similar characteristics to LS respondents aged 55 for sex and marital status, but the NCDS sample had lower levels of long-term limiting illness (19.7% vs 22.8%), non-white ethnicity (2.1% vs 11.7%) and living in South England (46.9% vs 50.1%), and higher levels of full-time employment (61.2% vs 55.2%), working in professional/higher managerial occupations (35.7% vs 29.2%), and living with a spouse (69.1% vs 64.9%), all p0.09) suggesting these NCDS findings are largely generalisable to the population of England and Wales.