Protein metabolism in rat tibialis anterior muscle after stimulated chronic eccentric exercise.
Protein metabolism in rat tibialis anterior muscle after stimulated chronic eccentric exercise.
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刺激慢性离心运动后大鼠胫骨前肌的蛋白质代谢。
DOI：
10.1152/jappl.1990.69.5.1718
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Booth,FW
中科院分区：
文献类型：
--
作者：
Wong,TS;Booth,FW
在另一项研究中（J.Appl.Physiol.69：1709-1717，1990），我们报道了腓肠肌（GAST）在每隔第3或第4天进行192次收缩的10周后没有发生肌肉增大。这个结果是令人惊讶的，因为增加的蛋白质合成速率是在最初的急性运动回合后用相同的范例确定的。在同一组动物中，在相同的慢性训练方案后，与久坐的对照肌肉相比，胫骨前肌（TA）肌肉扩大了16-30%。这表明GAST和TA肌肉之间的蛋白质表达的调节可能不同。本实验试图通过比较TA中蛋白质代谢的各种指标的变化与在GAST的伴随研究中确定的相同参数来定义和解释这些差异。在GAST，结果表明，TA蛋白合成率增加急性运动和主要由翻译和可能的翻译后机制调节。训练后GAST和TA肌肉之间的肌肉质量的差异反应可能部分是由于施加在TA上的相对阻力大于GAST上的相对阻力，这导致对蛋白质合成速率的更长时间的影响，刺激蛋白质合成增加所需的刺激收缩次数较少。数据还显示，虽然短至1分钟的总收缩持续时间（24次重复）增加了TA蛋白合成率的30%，8分钟的总收缩持续时间（192次重复）进一步增加TA蛋白合成率仅为对照组的45%以上。
In another study (J. Appl. Physiol. 69: 1709-1717, 1990) we reported that gastrocnemius (GAST) muscle enlargement failed to occur after 10 wk of 192 contractions performed every 3rd or 4th day. This result was surprising because increased protein synthesis rates were determined after an initial acute exercise bout with the same paradigms. In the same set of animals, tibialis anterior (TA) muscles were enlarged 16-30% compared with sedentary control muscles after the same chronic training regimen. This indicated that the regulation of protein expression may be different between the GAST and TA muscles. The present experiment attempted to define and explain these differences by comparing changes in various indexes of protein metabolism in TA with the same parameters determined in the accompanying study for the GAST. As in the GAST, results showed that TA protein synthesis rates are increased by acute exercise and principally regulated by translational and possibly posttranslational mechanisms. The differential response in muscle mass between the GAST and TA muscles after training may be due, in part, to greater relative resistances imposed on the TA than on the GAST that result in a more-prolonged effect on protein synthesis rates, with lower numbers of stimulated contractions required to stimulate increases in protein synthesis. Data also revealed that although as little as 1 min of total contractile duration (24 repetitions) increased TA protein synthesis rate by 30%, 8 min of total contractile duration (192 repetitions) further increased TA protein synthesis rates to only 45% above control.