Neurochemical regulation of oxytocin secretion in lactation.
Neurochemical regulation of oxytocin secretion in lactation.
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DOI：
10.1210/edrv-13-1-33
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发表时间：
1992-02
影响因子：
20.3
通讯作者：
W. R. Crowley;W. Armstrong
中科院分区：
文献类型：
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作者：
W. R. Crowley;W. Armstrong
I.简介：催产素分泌的生理模式九肽催产素（OT）是信使分子的一个很好的例子，具有不同的生理作用以及向其靶细胞递送的模式（1，2）。从神经垂体中的神经分泌末梢释放后，OT作为一种激素通过体循环输送到远处的靶器官，其中最重要的可能是乳腺和子宫（1）。此外，OT可能作为促垂体因子，从正中隆起的神经末梢释放到垂体门静脉系统中，以影响垂体前叶分泌（2-7），作为肽能神经递质或神经调质在中枢神经系统内作用，以影响各种神经内分泌、行为和自主神经功能（2，8-13），以及作为卵巢和睾丸中的旁分泌调节肽（14-18）。虽然其最广泛的研究在所有这些形式的生理作用都与...
I. Introduction: Physiological Patterns of Oxytocin Secretion THE nonapeptide oxytocin (OT) is an excellent example of a messenger molecule with diverse physiological actions as well as modes of delivery to its target cells (1, 2). After release from neurosecretory terminals in the neurohypophysis, OT exerts effects as a hormone carried by the systemic circulation to distant target organs, perhaps the most important of which are the mammary gland and uterus (1). In addition, OT may serve as a hypophyseotropic factor, released from nerve terminals in the median eminence into the pituitary portal vasculature, to affect anterior pituitary secretion (2–7), as a peptidergic neurotransmitter or neuromodulator acting within the central nervous system to influence a variety of neuroendocrine, behavioral, and autonomic functions (2, 8–13), and as a paracrine regulatory peptide in the ovary and testis (14–18). Although its most widely investigated physiological actions across all of these modalities are related to ...