Exogenous glucose oxidation during endurance exercise in hypoxia
Exogenous glucose oxidation during endurance exercise in hypoxia
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DOI：
10.14814/phy2.14457
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发表时间：
2020-07-01
影响因子：
2.5
通讯作者：
Goto, Kazushige
中科院分区：
文献类型：
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作者：
Sumi, Daichi;Hayashi, Nanako;Goto, Kazushige
目的：低氧耐力运动促进碳水化合物(CHO)代谢。然而，CHO的详细代谢仍不清楚。方法：9名健康男性健康体力活动者，在相同的能量消耗或相对运动强度下，在不同的时间进行了3个实验：(A)常氧下以常氧最大摄氧量的65%进行运动[NOR，吸入氧分数(FiO2)=20.9%，10.6+/-0.3 km/h]，(B)在相同的相对运动强度下进行NOR运动(HYPR，FiO2=14.5%，FIO2=14.5%，FIO2=14.5%)，9.4+/-0.3 km/h)和(C)与NOR相同的绝对运动强度(HYPA，FiO2=14.5%，10.6+/-0.3 km/h)。受试者在运动前立即摄入C-113标记的葡萄糖，并在运动中采集呼出气体样本以确定C-13排泄量(按(CO2)-C-13/(CO2)-C-12计算)。结果：HYPA运动诱导的血乳酸升高显著高于NOR和HYPR(p=.001)。与其他两个试验相比，HYPA在运动中涉及的呼吸交换比率(RER)显著更高(p
Purpose: Endurance exercise in hypoxia promotes carbohydrate (CHO) metabolism. However, detailed CHO metabolism remains unclear. The purpose of this study was to evaluate the effects of endurance exercise in moderate hypoxia on exogenous glucose oxidation at the same energy expenditure or relative exercise intensity.Methods: Nine active healthy males completed three trials on different days, consisting of 30 min of running at each exercise intensity: (a) exercise at 65% of normoxic maximal oxygen uptake in normoxia [NOR, fraction of inspired oxygen (FiO2) = 20.9%, 10.6 +/- 0.3 km/h], (b) exercise at the same relative exercise intensity with NOR in hypoxia (HYPR, FiO2 = 14.5%, 9.4 +/- 0.3 km/h), and (c) exercise at the same absolute exercise intensity with NOR in hypoxia (HYPA, FiO2 = 14.5%, 10.6 +/- 0.3 km/h). The subjects consumed C-113-labeled glucose immediately before exercise, and expired gas samples were collected during exercise to determine C-13-excretion (calculated by (CO2)-C-13/(CO2)-C-12).Results: The exercise-induced increase in blood lactate was significantly augmented in the HYPA than in the NOR and HYPR (p =.001). HYPA involved a significantly higher respiratory exchange ratio (RER) during exercise compared with the other two trials (p