The Effects of Alcohol Abuse on Pulmonary Alveolar-Capillary Barrier Function in Humans
The Effects of Alcohol Abuse on Pulmonary Alveolar-Capillary Barrier Function in Humans
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DOI：
10.1093/alcalc/agn051
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Moss, Marc
中科院分区：
文献类型：
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作者：
Burnham, Ellen L.;Halkar, Raghuveer;Moss, Marc
目标：酒精滥用与急性呼吸窘迫综合征的发生有关，这是一种以肺泡毛细血管通透性异常为特征的疾病。我们假设有酗酒史的人即使在没有症状的情况下也会有肺泡毛细血管通透性异常的临床证据。这可能有助于他们发展这种疾病的倾向。研究方法：33名有酗酒史但无其他疾病的受试者和13名年龄和吸烟匹配的对照组吸入Tc-99 m-DTPA（锝标记的二亚乙基三胺五乙酸酯;用于测量肺渗透性的同位素）3分钟，并测量90分钟内该同位素的洗脱。评估并比较受试者和对照组的肺清除率。结果如下：Tc-99 m-DTPA在酒精滥用受试者的肺中的半衰期显著短于在匹配的对照组中观察到的半衰期，即使校正伴随烟草使用的影响。当分别比较吸烟酒精滥用受试者和吸烟对照者的同位素半衰期时，酒精滥用受试者在肺部的同位素半衰期有缩短的趋势。当与不吸烟者进行比较时，情况也是如此。结论：这些观察结果提供了进一步的证据表明，酒精滥用影响肺泡毛细血管屏障的正常渗透性，从而可能有助于急性呼吸窘迫综合征的发展与酒精滥用的个人。
Aims: Alcohol abuse is associated with the development of the acute respiratory distress syndrome, a disorder characterized by abnormal alveolar-capillary permeability. We hypothesized that individuals with a history of alcohol abuse would have clinical evidence of abnormal alveolar-capillary permeability even in the absence of symptoms. This could contribute to their propensity for the development of this disorder. Methods: Thirty-three subjects with a history of alcohol abuse, but no other medical problems, and 13 age- and smoking-matched controls inhaled Tc-99m-DTPA (technetium-labeled diethylenetriamine penta-acetate; an isotope used to measure lung permeability) for a 3-min period, and washout of this isotope was measured for a 90-min period. The rate at which it was cleared from the lungs was assessed and compared between subjects and controls. Results: The half-life of Tc-99m-DTPA in the lungs of subjects with alcohol abuse was significantly shorter than that observed in matched controls, even when correcting for the effects of concomitant tobacco use. When the half-life of the isotope for smoking alcohol-abusing subjects and smoking controls were compared separately, there was a trend for the alcohol-abusing subjects to have a shorter half-life of the isotope present in the lungs. This was also true when non-smokers were compared. Conclusions: These observations provide further evidence that alcohol abuse affects the normal permeability of the alveolar-capillary barrier and thereby may contribute to the development of the acute respiratory distress syndrome in individuals with alcohol abuse.