Genetics of mouse growth.
Genetics of mouse growth.
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DOI：
10.1387/ijdb.9853827
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
A. Efstratiadis
中科院分区：
文献类型：
--
作者：
A. Efstratiadis
在发育过程中，哺乳动物生物体的大小增加，直到达到一个极限，这主要是由细胞分裂的发生率和持续时间增加总细胞数决定的。这一过程主要由参与通过全身或局部效应促进或抑制生长的途径的基因的行为的编排来调节。这种生长控制基因及其对细胞周期的影响的观点已经开始从转基因和基因敲除实验的结果中出现，这些实验也重新强调了一些生长因子和激素在生长信号传导中的重要作用，尽管关于生长与模式化、分化和形态发生的协调的机制关系和细节仍然很难理解。
During development, mammalian organisms increase in size until a limit is reached that is mainly determined by the rate and duration of occurrence of cellular divisions increasing total cell number. This process is mostly regulated by an orchestration of the actions of genes participating in pathways that promote or inhibit growth through systemic or local effects. This view of growth control genes and of their effects on the cell cycle has begun emerging from the results of transgenic and gene knockout experiments, which have also re-emphasized the central involvement of some growth factors and hormones in growth signaling, although mechanistic relationships and details about the coordination of growth with patterning, differentiation and morphogenesis continue to remain largely elusive.