Atrophy of foot muscles
Atrophy of foot muscles
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DOI：
10.2337/diacare.27.10.2382
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发表时间：
2004-10-01
期刊：
影响因子：
16.2
通讯作者：
Jakobsen, J
中科院分区：
文献类型：
--
作者：
Andersen, H;Gjerstad, MD;Jakobsen, J
目的：糖尿病神经病变是一种长度依赖的过程，在某些患者中会导致肌力下降和腿部肌肉萎缩。我们假设在糖尿病神经病变中足部固有肌肉萎缩，萎缩程度是与神经病变过程密切相关的运动功能障碍的量度。研究设计与方法：对23例长期糖尿病伴(n=15)和无(n=8)慢性神经病变的糖尿病患者和23例匹配的健康非糖尿病对照组足部固有肌(VFM)进行连续横断面磁共振成像的体视学测定。根据临床检查、神经传导检查和定量感觉检查，计算每个患者的神经病变等级总分。结果：神经病患者、非神经病患者和健康对照组的VFm分别为86+/-52、165+/-34和168+/-42 cm(3)(P<；0.001)。神经病变等级总分与VFM呈负相关(r=0.75，P<；1×10(-5))。结论糖尿病神经病变患者足部肌肉总体积减半。足部肌肉萎缩与神经病变的严重程度密切相关，并反映运动功能障碍。
OBJECTIVE - Diabetic neuropathy is a length-dependent process that leads to reduced muscle strength and atrophy of leg muscles in some patients. We hypothesized that intrinsic foot muscles are atrophied in diabetic neuropathy and that the degree of atrophy is a measure of motor dysfunction closely related to the neuropathic process.RESEARCH DESIGN AND METHODS - Consecutive cross-sectional magnetic resonance images of the nondominant foot were obtained for stereological determination of the total volume of the intrinsic foot muscles (VFM) in 23 long-term diabetic patients with (n = 15) and without (n = 8) chronic neuropathy and in 23 matched healthy nondiabetic control subjects. Based on clinical examination, nerve conduction studies, and quantitative sensory examination, a neuropathy rank-sum score was calculated foi- each patient.RESULTS- Total VFM was 86 +/- 52, 165 +/- 34, and 168 +/- 42 cm(3) in neuropathic patients, nonneuropathic patients, and healthy control subjects, respectively (P < 0.001). There was a close inverse relationship between the neuropathy rank-sum score and the VFM (r = 0.75, P < 1 X 10(-5)).CONCLUSIONS-Total volume of the foot muscles is halved in patients with diabetic neuropathy. Atrophy of foot muscles is closely related to the severity of neuropathy and reflects motor dysfunction.