Host pregnancy influences the establishment of Trichinella zimbabwensis in Balb C mice.
Host pregnancy influences the establishment of Trichinella zimbabwensis in Balb C mice.
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DOI：
10.1007/s12639-017-0891-9
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发表时间：
2017-09-01
期刊：
影响因子：
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通讯作者：
Mukaratirwa, Samson
中科院分区：
文献类型：
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作者：
Hlaka, Lerato;Chitanga, Simbarashe;Mukaratirwa, Samson
为了确定宿主妊娠对津巴布韦旋毛虫建立的影响，将120只雌性Balb C小鼠分为4组，每组30只。第1组动物在第0天每克体重（LPG）口腔感染50只津巴布韦锥虫幼虫；第二组在第0天交配，未感染；第3组在交配后第0天交配，在交配后第7天感染50 LPG；第4组为对照组，既不交配也不感染。每组处死6只，分别于感染后第0、7、14、21、28天测定各组肠道内成虫数量和肌肉内幼虫数量；第2组为交尾后0、7、14、21和28天，第3组为交尾后7、14、21、28和35天。此外，在相同的时间间隔内测量所有组的黄体酮和皮质醇水平。我们的研究结果表明，怀孕减少了Balb C小鼠肌肉中幼虫的数量，孕激素水平显著高于未怀孕的Balb C小鼠(P
In order to determine the effect of host pregnancy in the establishment of Trichinella zimbabwensis, 120 female Balb C mice were divided into 4 groups of 30 mice each. Group 1 animals were orally infected with 50 T. zimbabwensis larvae per gram (LPG) of body weight on day 0; group 2 were mated on day 0 and not infected; group 3 were mated at day 0 and infected with 50 LPG at day 7 post-mating and Group 4 were control animals which were neither mated nor infected. Six animals from each group were sacrificed and the number of adult parasites in the intestines as well as larvae in the muscles were determined at day 0, 7, 14, 21 and 28 post-infection for group 1; 0, 7, 14, 21 and 28 post-mating for group 2 and days 7, 14, 21, 28 and 35 post-mating for group 3. In addition, levels of progesterone and cortisol were measured in all groups at the same intervals. Our results showed that pregnancy reduced the number of larvae establishing in muscles with progesterone levels significantly higher in pregnant than in non-pregnant Balb C mice (P