Relationships between anaemia and parasitic infections in Kenyan schoolchildren: A Bayesian hierarchical modelling approach
Relationships between anaemia and parasitic infections in Kenyan schoolchildren: A Bayesian hierarchical modelling approach
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DOI：
10.1016/j.ijpara.2008.05.013
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发表时间：
2008-12-01
影响因子：
4
通讯作者：
Brooker, Simon
中科院分区：
文献类型：
--
作者：
Koukounari, Artemis;Estambale, Benson B. A.;Brooker, Simon
贫血是多因素的起源和解开其病因仍然存在问题，令人惊讶的是，很少有研究调查不同的寄生虫感染的相对贡献，在学龄儿童贫血。我们报告血红蛋白，疟疾的横截面数据。在肯尼亚西部的30所小学，对5年级和6年级的1 523名在校儿童（10-21岁）进行了寄生虫病、蠕虫感染和营养不良的调查。贝叶斯层次模型被用来调查推定的关系。发现感染恶性疟原虫或严重感染曼氏血吸虫的儿童、发育不良的儿童和女童血红蛋白浓度较低。严重感染S.与未受感染的儿童相比，曼索尼人也更有可能贫血。这项研究进一步强调了疟疾和肠道血吸虫病对降低学龄儿童血红蛋白水平的重要性，并有助于指导在不同寄生虫传播地区实施综合学校卫生方案。(C)2008年澳大利亚寄生虫学会由爱思唯尔有限公司出版。保留所有权利。
Anaemia is multi-factorial in origin and disentangling its aetiology remains problematic, with surprisingly few studies investigating the relative contribution of different parasitic infections to anaemia amongst schoolchildren. We report cross-sectional data on haemoglobin, malaria. parasitaemia, helminth infection and undernutrition among 1523 schoolchildren enrolled in classes 5 and 6 (aged 10-21 years) in 30 primary schools in western Kenya. Bayesian hierarchical modelling was used to investigate putative relationships. Children infected with Plasmodium falciparum or with a heavy Schistosoma mansoni infection, stunted children and girls were found to have lower haemoglobin concentrations. Children heavily infected with S. mansoni were also more likely to be anaemic compared with uninfected children. This Study further highlights the importance of malaria and intestinal schistosomiasis as contributors to reduced haemoglobin levels among schoolchildren and helps guide the implementation of integrated school health programmes in areas of differing parasite transmission. (C) 2008 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.