Predominance of the Hungarian clone (ST 239-III) among hospital-acquired meticillin-resistant Staphylococcus aureus isolates recovered throughout mainland China
Predominance of the Hungarian clone (ST 239-III) among hospital-acquired meticillin-resistant Staphylococcus aureus isolates recovered throughout mainland China
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DOI：
10.1016/j.jhin.2008.10.029
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发表时间：
2009-03-01
影响因子：
6.9
通讯作者：
Pan, W. B.
中科院分区：
文献类型：
--
作者：
Xu, B. L.;Zhang, G.;Pan, W. B.
多位点序列分型（MLST）数据揭示了金黄色葡萄球菌全球流行病学的许多见解，但除了日本等显著例外，大多数亚洲国家的证据目前有限。本研究对2002年在中国大陆收集的132株医院获得性耐甲氧西林金黄色葡萄球菌（HA-MRSA）进行了MLST分析。从广州一家三级医院共分离得到102株分离株，其余30株分离株来自6家大都市三级医院，分布在地理上不同的地区，总面积超过200万公里(2)。数据显示，在中国大陆，一个单克隆谱系ST 239具有显著优势，占132个分离株的97%。这些数据支持了先前研究中更有限的证据，表明ST 239在中国医院中普遍占主导地位，这种模式可能延伸到整个亚洲大陆。葡萄球菌染色体盒mec （SCCmec）分型证实了ST 239分离株的同质性，绝大多数与匈牙利克隆（ST 239- iii）相对应。(C) 2008医院感染学会。Elsevier Ltd.出版。版权所有。
Multilocus sequence typing (MLST) data have revealed many insights into the global epidemiology of Staphylococcus aureus but, with notable exceptions such as Japan, the evidence from most Asian countries is currently limited. Here we have applied MLST to 132 hospital-acquired meticillin-resistant Staphylococcus aureus (HA-MRSA) isolates collected in mainland China in 2002. In all, 102 isolates were recovered from a single tertiary hospital in Guangzhou, South China, and the remaining 30 isolates were recovered from six metropolitan tertiary hospitals from geographically diverse districts corresponding to a total area of more than 2 million km(2). The data reveal a striking predominance throughout mainland China of a single clonal lineage, ST 239, which accounts for 97% of the 132 isolates. These data support more limited evidence from previous studies suggesting the widespread predominance of ST 239 throughout hospitals in China, a pattern which possibly extends to the whole of continental Asia. Staphylococcal chromosome cassette mec (SCCmec) typing confirmed the homogeneity of the ST 239 isolates, with the vast majority corresponding to the Hungarian clone (ST 239-III). (C) 2008 The Hospital Infection Society. Published by Elsevier Ltd. All rights reserved.