Hepatic myofibroblasts: A heterogeneous population of multifunctional cells in liver fibrogenesis
Hepatic myofibroblasts: A heterogeneous population of multifunctional cells in liver fibrogenesis
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DOI：
10.1016/j.biocel.2009.03.010
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发表时间：
2009-11-01
影响因子：
4
通讯作者：
Parola, Maurizio
中科院分区：
文献类型：
--
作者：
Novo, Erica;di Bonzo, Lorenzo Valfre;Parola, Maurizio
肝肌成纤维细胞是一种高度增殖的异质细胞群。促纤维化细胞、促炎症细胞、促血管生成细胞和收缩细胞支持不同病因的慢性肝病的肝纤维化和纤维化进展，直至常见的肝硬化晚期。这些α -平滑肌肌动蛋白阳性的肌成纤维细胞样细胞，根据目前的文献，主要是通过一个激活和反分化的过程产生的，该过程涉及肝星状细胞或门静脉区成纤维细胞。肝肌成纤维细胞也可以来源于骨髓来源的细胞，包括间充质干细胞或能够移植慢性损伤肝脏的循环纤维细胞。在某些情况下。通过包括肝细胞和胆管细胞在内的上皮细胞向间质细胞转变的过程。肝肌成纤维细胞也可能在调节免疫反应和与肝祖细胞（干细胞）以及原发性肝细胞癌或转移性癌的恶性细胞的串扰中发挥重要作用(C) 2009 Elsevier Ltd版权所有。
Hepatic myofibroblasts constitute a heterogenous population of highly proliferative. pro-fibrogenic, pro-inflammatory, pro-angiogenic and contractile cells that sustain liver fibrogenesis and then fibrotic progression of chronic liver diseases of different aetiology to the common advanced-stage of cirrhosis These alpha-smooth muscle actin-positive myofibroblast-like cells, according to current literature, mainly originate by a process of activation and trans-differentiation that involves either hepatic stellate cells or fibroblasts of portal areas. Hepatic myofibroblasts can also originate from bone marrow-derived cells, including mesenchymal stem cells or circulating fibrocytes able to engraft chronically injured liver, as well as. in certain conditions. by a process of epithelial to mesenchymal transition involving hepatocytes and cholangiocytes. Hepatic myofibroblasts may have also additional crucial roles in modulating immune response and in the cross talk with hepatic progenitor (stem) cells as well as with malignant cells of either primary hepatocellular carcinomas or of metastatic cancers (C) 2009 Elsevier Ltd All rights reserved.