Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis
Histology of the ligamentum flavum in patients with degenerative lumbar spinal stenosis
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DOI：
10.1007/s005860050181
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发表时间：
1999-08-01
影响因子：
2.8
通讯作者：
Dvorak, J
中科院分区：
文献类型：
--
作者：
Schräder, PK;Grob, D;Dvorak, J
对退变性腰椎管狭窄症患者黄韧带钙化程度和弹性纤维结构变化进行了评价，并与无椎管狭窄症患者的结果进行了比较。对21例腰椎管狭窄症患者（男13例，女8例）进行了黄韧带切除、组织学处理和染色。用计算机图像分析系统对钙化、弹性纤维/胶原纤维比值以及纤维形态进行评价。作为对照组，10具尸体的20条韧带以同样的方式处理。使用Mann-Whitney-Wilcoxon检验（α = 0.05）和t检验（α = 0.05）对结果进行统计学分析。腰椎管狭窄症患者的韧带几乎全部钙化（平均0.17%，最高3.8%），并出现相应的纤维化，弹性纤维/胶原纤维比值降低。年龄与组织学改变有显著相关性（P <0.05）。在对照组中，我们仅在20个节段中的3个节段中发现了极轻微的钙化（平均0.015%）。未发现相关的纤维化，弹性纤维的构型：未显示任何病理变化。本研究的结果说明了黄韧带的组织学改变在腰椎管狭窄症病因学中的重要作用。
The degree of calcification as well as the structural changes of the elastic fibres in the ligamentum flavum in patients with degenerative lumbar spinal stenosis were evaluated and the results were compared to those of patients without spinal stenosis. In 21 patients (13 male, 8 female) with lumbar spinal stenosis the ligamentum flavum was removed, histologically processed and stained. The calcification, the elastic/collagenous fibre ratio as well as the configuration of the fibres were evaluated with an image analyzing computer. As a control group, 20 ligaments of 10 human corpses were processed in the same way. The results were statistically analysed using the Mann-Whitney-Wilcoxon test (alpha = 0.05) and the t-test (alpha = 0.05). Nearly all the ligaments of patients with lumbar spinal stenosis were calcified (average 0.17%, maximum 3.8%) and showed relevant fibrosis with decreased elastic/collagenous fibre ratio. There was a significant correlation between age and histological changes (P < 0.05). In the control group we only found minimal calcification in 3 of 20 segments (average 0.015%). No relevant fibrosis was found and the configuration of elastic fibres: showed no pathologic changes. The results of this study illustrate the important role of histological changes of the ligamentum flavum for the aetiology of lumbar spinal stenosis.