Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants
Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants
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DOI：
10.1016/j.phymed.2003.06.006
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发表时间：
2005-01-01
期刊：
影响因子：
7.9
通讯作者：
Jalil, J
中科院分区：
文献类型：
--
作者：
Jantan, I;Rafi, IAA;Jalil, J
以H-3-PAF为配体，研究了马来西亚37种药用植物49种甲醇提取物对血小板活化因子（PAF）与家兔血小板结合的抑制作用。其中，姜科6种植物（Alpinia galanga Swartz）的提取物。Boesenbergia pandurata Roxb。，黄姜黄，铜绿假姜黄。，红玫瑰。和Z. zerumbet Koenig.)，两个肉桂种（C. altissimum Kosterm.）。和C. pubescens Kochummen), Goniothalamus malayanus Hook。f.苦瓜。和沙刺草是新的PAF拮抗剂的潜在来源，因为它们具有显著的抑制作用，IC50值在1.2至18.4马克毫升（-1）之间。(C) 2004 Elsevier GmbH版权所有。
Forty-nine methanol extracts of 37 species of Malaysian medicinal plants were investigated for their inhibitory effects on platelet-activating factor (PAF) binding to rabbit platelets, using H-3-PAF as a ligand. Among them, the extracts of six Zingiberaceae species (Alpinia galanga Swartz., Boesenbergia pandurata Roxb., Curcuma ochorrhiza Val., C. aeruginosa Roxb., Zingiber officinale Rose. and Z. zerumbet Koenig.), two Cinnamomum species (C. altissimum Kosterm. and C. pubescens Kochummen.), Goniothalamus malayanus Hook. f. Momordica charantia Linn. and Piper aduncum L. are potential sources of new PAF antagonists, as they showed significant inhibitory effects with IC50 values ranging from 1.2 to 18.4 mug ml(-1). (C) 2004 Elsevier GmbH. All rights reserved.