CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)
CONTROL OF DIMENSIONAL STABILITY AND DEGRADATION RATE IN ELECTROSPUN COMPOSITE SCAFFOLDS COMPOSED OF POLY(D,L-LACTIDE-co-GLYCOLIDE) AND POLY(ε-CAPROLACTONE)
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DOI：
10.1142/s0256767908002674
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发表时间：
2008-01
影响因子：
4.3
通讯作者：
Yijiang Liu;Hongliang Jiang;Y. Li;K. Zhu
中科院分区：
文献类型：
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作者：
Yijiang Liu;Hongliang Jiang;Y. Li;K. Zhu
本研究的目的是研究聚（D,L-丙交酯-共-乙交酯）/聚（ε-己内酯）（PLGA/PCL）共混组合物对电纺纤维的形态、收缩和降解行为的影响。随着复合纤维中PLGA含量的增加，电纺纤维的平均直径从1.35μm增加到1.95μm。由于 PCL 的半结晶性质，可以通过在纤维中添加 20% PCL 来避免电纺 PLGA 网的严重收缩。电纺丝网的降解速率可以通过 PLGA/PCL 成分来调节。此外，含有 20% PCL 的静电纺丝网在降解过程中表现出稳定的尺寸形态。
The purpose of this study is to investigate the effect of composition poly(D,L-lactide-co-glycolide)/poly(e-caprolactone) (PLGA/PCL) blending on the morphology, shrinkage and degradation behaviors of the electrospun fibers. With the increase of PLGA content in the composite fibers, the average diameter of the electrospun fibers increased from 1.35 μm to 1.95 μm. The serious shrinking of the electrospun PLGA meshes could be circumvented by adding 20% PCL in the fibers, resulting from the semi-crystalline nature of PCL. The degradation rate of the electrospun meshes could be modulated by PLGA/PCL composition. In addition, the electrospun meshes containing 20% PCL displayed stable dimensional morphology with degradation.