Segregation analysis of diabetic nephropathy in Pima Indians
Segregation analysis of diabetic nephropathy in Pima Indians
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DOI：
10.2337/diabetes.49.6.1049
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发表时间：
2000-06-01
期刊：
影响因子：
7.7
通讯作者：
Hanson, RL
中科院分区：
文献类型：
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作者：
Imperatore, G;Knowler, WC;Hanson, RL
糖尿病肾病的家族聚集性表明，除了那些导致糖尿病的基因外，还存在决定肾病易感性的基因。在本研究中，进行了复杂的分离分析，在糖尿病患者的皮马印第安人家庭，以确定是否在这个人口中的肾病家族聚集性可以反映一个单一的主要基因的作用。肾病定义为尿蛋白/肌酐比值（PCR）大于或等于500 mg/g，在C类回归logistic模型中作为离散性状进行分析。PCR个体
Familial aggregation of diabetic nephropathy suggests the existence of genes determining susceptibility to nephropathy in addition to those leading to diabetes. In the present study, complex segregation analysis was performed in diabetic members of Pima Indian families to determine whether familial aggregation of nephropathy in this population could reflect the action of a single major gene. Nephropathy, defined by a urinary protein-to-creatinine ratio (PCR) greater than or equal to 500 mg/g, was analyzed as a discrete trait in a class C regressive logistic model. Individuals with PCR