Active cortical dendrites modulate perception
Active cortical dendrites modulate perception
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DOI：
10.1126/science.aah6066
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发表时间：
2016-12-23
期刊：
影响因子：
56.9
通讯作者：
Larkum, Matthew E.
中科院分区：
文献类型：
--
作者：
Takahashi, Naoya;Oertner, Thomas G.;Larkum, Matthew E.
关于感知的神经基础以及它如何在机械水平上运作，目前还没有达成共识。研究人员发现，小鼠初级体感皮层（S1）第5层（L5）锥体神经元亚群顶端树突的Ca2+活性与感知检测晶须挠度的阈值相关。操纵顶端树突的活动改变了感知阈值，表明活跃的树突机制与感知检测有因果关系。
There is as yet no consensus concerning the neural basis of perception and how it operates at a mechanistic level. We found that Ca2+ activity in the apical dendrites of a subset of layer 5 (L5) pyramidal neurons in primary somatosensory cortex (S1) in mice is correlated with the threshold for perceptual detection of whisker deflections. Manipulating the activity of apical dendrites shifted the perceptual threshold, demonstrating that an active dendritic mechanism is causally linked to perceptual detection.