Oxidant stress and essential fatty acids in patients with risk and established ARDS
Oxidant stress and essential fatty acids in patients with risk and established ARDS
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DOI：
10.1016/s0009-8981(00)00264-3
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发表时间：
2000-08-01
影响因子：
5
通讯作者：
Naidu, MUR
中科院分区：
文献类型：
--
作者：
Kumar, KV;Rao, SM;Naidu, MUR
氧自由基是生理和病理事件的重要介质。在急性肺损伤中，活化的淋巴细胞刺激肿瘤坏死因子（TNF）和其他细胞因子。这些淋巴因子增加了多形核白细胞（PMNLs）、巨噬细胞和其他可能最终产生急性呼吸窘迫综合征（ARDS）的细胞产生自由基。我们在这里提出的结果支持了这一点，因为在已确诊的ARDS患者中，脂质过氧化产物显著增加。与有ARDS风险的患者相比，已建立ARDS组的脂质过氧化量明显更高。与对照组和有ARDS风险的患者相比，已确诊ARDS患者的一氧化氮浓度显著降低。血浆磷脂组分的脂肪酸分析显示，n-6系列的亚油酸、γ -亚麻酸、二同型γ -亚麻酸和花生四烯酸水平显著降低，n-3系列的α -亚麻酸、二十碳五烯酸、二十二碳己烯酸水平显著降低。有ARDS风险的患者体内n-6系列γ -亚麻酸、α -亚麻酸和n-3系列二十碳五烯酸水平降低。这些结果提示脂质过氧化物和必需脂肪酸代谢的改变可能在ARDS的发病机制中起作用。(C) 2000 Elsevier Science B.V.版权所有
Oxygen free radicals are important mediators of both physiological and pathological events. In acute lung injury, the activated lymphocytes stimulate tumor necrosis factor (TNF) and other cytokines. These lymphokines augment free radical generation by polymorphonuclear leukocytes (PMNLs), macrophages and other cells which may ultimately produce acute respiratory distress syndrome (ARDS). This is supported by our results presented here in that there is a significant increase in lipid peroxidation products in patients with established ARDS. The amount of lipid peroxidation was significantly higher Pn the established ARDS group compared to patients who are at risk for ARDS. Nitric oxide concentrations were significantly decreased in established ARDS compared to the control and those who are at risk for ARDS. Fatty acid analysis of the plasma phospholipid fraction revealed a significant decreased in linoleic acid, gamma-linolenic acid, dihomo-gamma-linolenic acid and arachidonic acid levels of n-6 series and alpha-linolenic acid, eicosapentaenoic acid, docosa-hexanenoic acid of n-3 series. Patients who are at risk for ARDS have decreased levels of gamma-linolenic acid of the n-6 series, alpha-linolenic acid and eicosapentaenoic acid of the n-3 series. These results suggest that lipid peroxides and alteration in essential fatty acid metabolism may have a role in the pathogenesis of ARDS. (C) 2000 Elsevier Science B.V. All rights reserved.