SUBCLINICAL THOUGHT-DISORDER IN FIRST-DEGREE RELATIVES OF SCHIZOPHRENIC-PATIENTS - RESULTS FROM A MATCHED-PAIRS STUDY WITH THE THOUGHT-DISORDER INDEX
SUBCLINICAL THOUGHT-DISORDER IN FIRST-DEGREE RELATIVES OF SCHIZOPHRENIC-PATIENTS - RESULTS FROM A MATCHED-PAIRS STUDY WITH THE THOUGHT-DISORDER INDEX
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DOI：
10.1111/j.1600-0447.1995.tb09587.x
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发表时间：
1995-10-01
影响因子：
6.7
通讯作者：
FRANKE, P
中科院分区：
文献类型：
--
作者：
HAIN, C;MAIER, W;FRANKE, P
为了评估精神分裂症患者及其一级亲属形式思维障碍的频率和质量，对36名未接受药物治疗的患者、这些患者的20名兄弟姐妹和37名正常对照受试者进行了连续系列的霍尔兹曼思维障碍指数（TDI），作为该工具内部有效性的证明，通过TDI总分和各分项得分的测量，患者表现出比对照组明显更多的思维障碍，这证明了该工具在德语样本中的内部效度。此外，在与年龄和性别匹配的对照组的成对比较中，患者的兄弟姐妹的TDI总分显著较高，几个分项得分（组合和轻率）无显著升高。至于严重程度的思维障碍，兄弟姐妹大多采取了中间的位置之间的患者和控制。结合其他作者以前的报道，我们的研究结果进一步支持了亚临床思维障碍作为精神分裂症家族易感性指标的概念。
To assess the frequency and quality of formal thought disorder in schizophrenic patients and their first-degree relatives, a consecutive series of 36 unmedicated patients, 20 siblings of these patients and 37 normal control subjects were examined with Holzman's Thought Disorder Index (TDI), As a proof of the internal validity of this tool, the patients demonstrated significantly more thought disorder than the controls as measured by the TDI total score and various subscores, which proved the internal validity of this tool in a German-speaking sample. In addition, in a pairwise comparison with controls who were individually matched by age and sex the patients' siblings had a significantly higher total TDI score and nonsignificant elevations on several subscores (combinatory and flippant). As to the level of severity of the thought disorder, the siblings mostly took an intermediate position between patients and controls. In conjunction with previous reports from other authors, our findings lend further support to the notion of subclinical thought disorder as an indicator of familial vulnerability to schizophrenia.