Field investigations of tularemia in Norway
Field investigations of tularemia in Norway
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DOI：
10.1111/j.1574-695x.1996.tb00235.x
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发表时间：
1996-03-01
影响因子：
--
通讯作者：
Scheel, O
中科院分区：
文献类型：
--
作者：
Berdal, BP;Mehl, R;Scheel, O
在挪威，兔热病是小型啮齿动物和野兔种群中的常见疾病，可以观察到大规模爆发。在人类中，每年的病例数很低，通常不到10例，近年来记录的峰值高达44例。然而，对猎人和健康学龄儿童的血清学调查表明，在后一组中高达4.7%的阳性率，土拉热弗朗西斯菌低度感染是普遍的。F.土拉热菌与阿米巴原虫（例如卡氏Achantamoebacastellanii）共培养后可在内化后生长并杀死阿米巴原虫。与军团菌一样，弗朗西斯菌的毒力可能在原生动物摄入后增强。这表明有一种机制可以解释我们区域的传播和感染模式。
In Norway, tularemia is a common disease in small rodent and hare populations, where large outbreaks can be observed. In humans, the yearly number of cases is low, usually less than ten, with peaks up to 44 recorded in recent years. Serological investigations on hunters and healthy school children nevertheless indicate, with up to 4.7% positivity in the latter group, that Francisella tularensis low-grade infection is widespread. F. tularensis in co-culture with amoebae, e.g. Achantamoeba castellanii, may grow after internalization and kill the amoeba. As with Legionella, Francisella virulence may be enhanced after protozoan ingestion. This suggests a mechanism that can explain the pattern of dissemination and infection in our region.