Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study
Cholinesterase alterations in delirium after cardiosurgery: a German monocentric prospective study
复制标题
DOI：
10.1136/bmjopen-2019-031212
复制
发表时间：
2020-01-01
期刊：
影响因子：
2.9
通讯作者：
Scheller, Bertram
中科院分区：
文献类型：
--
作者：
Adam, Elisabeth Hannah;Haas, Victoria;Scheller, Bertram
目的术后谵妄（POD）是择期心脏手术后的常见并发症。最近的证据表明，胆碱能系统正常活动的破坏可能与谵妄有关。设计前瞻性观察研究。在欧洲学术医院设置单中心。主要和次要结果测量在我们的研究中，在术前以及术后第一天和第二天测定了乙酰胆碱酯酶（AChE）和丁酰胆碱酯酶（BChE）的酶活性。采用重症监护病房的混乱评估方法来筛查患者是否存在POD。结果共有114名患者纳入研究。 POD 与术后第 1 天 BChE 活性降低相关 (p=0.03)。此外，发生 POD 的患者术前 AChE 活性显着低于未发生 POD 的患者 (p
ObjectivesPostoperative delirium (POD) is a common complication after elective cardiac surgery. Recent evidence indicates that a disruption in the normal activity of the cholinergic system may be associated with delirium.DesignProspective observational study.SettingSingle-centre at a European academic hospital.Primary and secondary outcome measuresIn our study the enzyme activities of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) were determined preoperatively as well as on the first and second postoperative day. The confusion assessment method for the intensive care unit was used to screen patients for the presence of POD.ResultsA total of 114 patients were included in the study. POD was associated with a decrease in BChE activity on postoperative day 1 (p=0.03). In addition, patients who developed POD, had significantly lower preoperative AChE activity than patients without POD (p