Role of the renin-angiotensin system in age-related sarcopenia and diastolic dysfunction.
Role of the renin-angiotensin system in age-related sarcopenia and diastolic dysfunction.
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DOI：
10.2217/1745509x.4.1.37
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发表时间：
2008-02-01
期刊：
影响因子：
--
通讯作者：
Groban, Leanne
中科院分区：
文献类型：
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作者：
Carter, Christy S;Groban, Leanne
这篇综述的目的是描述最近的药理学和遗传学研究如何有助于我们了解肾素-血管紧张素系统（RAS）在年龄相关性肌肉减少症和舒张功能障碍中的作用。在这两种情况下，治疗策略是有限的，尽管干预措施，包括RAS阻断（使用血管紧张素转换酶抑制剂和血管紧张素受体阻滞剂）是成功的，并导致改善功能的结果，不一定是由药物的血流动力学效应介导的。在肌肉减少症和舒张功能障碍的动物模型中的研究指出RAS阻断对多种生物学机制的普遍影响，包括炎症、氧化损伤和代谢失调。因此，应考虑在其他条件下重新评估这些药物的使用，以维持老年人的功能独立性。
The purpose of this review is to describe how recent pharmacological and genetic studies have contributed to our understanding of the role of the renin-angiotensin system (RAS) in age-related sarcopenia and diastolic dysfunction. Treatment strategies are limited in the context of both of these conditions, although interventions, which include blockade of the RAS (using angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers) are successful and lead to improvements in functional outcomes that are not necessarily mediated by hemodynamic effects of the drugs. Studies in animal models of sarcopenia and diastolic dysfunction point to ubiquitous effects of RAS blockade on multiple biological mechanisms, including inflammation, oxidative damage and metabolic dysregulation. Therefore, a re-evaluation of the use of these drugs in other conditions should be considered for maintaining functional independence in older individuals.