Swine workers and swine influenza virus infections.
Swine workers and swine influenza virus infections.
复制标题
DOI：
10.3201/eid1312.061323
复制
发表时间：
2007-12
影响因子：
11.8
通讯作者：
Alavanja MC
中科院分区：
文献类型：
--
作者：
Gray GC;McCarthy T;Capuano AW;Setterquist SF;Olsen CW;Alavanja MC
养猪工人及其配偶感染猪流感病毒的风险明显增加。2004年，803名来自农业健康研究的爱荷华州农村居民参加了一项为期2年的人畜共患流感传播的前瞻性研究。从入组、12个月和24个月随访中获得的人口统计学和职业暴露数据与既往和偶发流感病毒感染证据的相关性进行了检查。当使用多变量调整的比例优势模型时，在入组时，猪暴露的参与者（比值比[OR] 54.9，95%置信区间[CI] 13.0-232.6）及其非猪暴露配偶（或28.2，95%CI 6.1-130.1），发现猪流感（H1N1）抗体水平升高的几率增加与爱荷华州大学的79名未暴露人员相比，职业性猪流感病毒感染的进一步证据是通过自我报告的流感样疾病数据，比较入组和随访血清样本，以及从患病养猪户中分离出的疑似猪流感（H1N1）病毒观察到的。研究数据表明，养猪工人及其非猪暴露配偶感染人畜共患流感病毒的风险增加。
Swine workers and their spouses are at markedly increased risk of acquiring swine influenza virus infections. In 2004, 803 rural Iowans from the Agricultural Health Study were enrolled in a 2-year prospective study of zoonotic influenza transmission. Demographic and occupational exposure data from enrollment, 12-month, and 24-month follow-up encounters were examined for association with evidence of previous and incident influenza virus infections. When proportional odds modeling with multivariable adjustment was used, upon enrollment, swine-exposed participants (odds ratio [OR] 54.9, 95% confidence interval [CI] 13.0–232.6) and their nonswine-exposed spouses (OR 28.2, 95% CI 6.1–130.1) were found to have an increased odds of elevated antibody level to swine influenza (H1N1) virus compared with 79 nonexposed University of Iowa personnel. Further evidence of occupational swine influenza virus infections was observed through self-reported influenza-like illness data, comparisons of enrollment and follow-up serum samples, and the isolation of a reassortant swine influenza (H1N1) virus from an ill swine farmer. Study data suggest that swine workers and their nonswine-exposed spouses are at increased risk of zoonotic influenza virus infections.