Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection
Expression of cytoskeleton-associated protein 4 is related to lymphatic metastasis and indicates prognosis of intrahepatic cholangiocarcinoma patients after surgery resection
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细胞骨架相关蛋白4的表达与肝内胆管癌术后淋巴转移相关并提示预后
DOI：
10.1016/j.canlet.2013.05.003
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发表时间：
2013-09-01
期刊：
影响因子：
9.7
通讯作者：
Wang, Hong-yang
中科院分区：
文献类型：
--
作者：
Li, Min-hong;Dong, Li-wei;Wang, Hong-yang
本研究的目的是探讨CKAP 4在肝内胆管细胞癌（ICC）中的临床意义。在包含173例ICC患者的队列中测定CKAP 4表达。我们发现CKAP 4在大多数ICC病例中过表达，并且与肿瘤大小、远处转移、淋巴结转移、UICC和TNM分期特征显著相关。Kaplan-Meier和考克斯回归数据表明，CKAP 4与良好的临床结局相关，是总生存期的独立预测因子（HR，0.646; 95% CI，0.463-0.900 [p = 0.010]）。因此，CKAP 4可作为ICC患者的预后标志物。(C)2013爱思唯尔爱尔兰有限公司版权所有。
The objective of the study was to investigate the clinical significance of CKAP4 in intrahepatic cholangio-cellular carcinoma (ICC). CKAP4 expression was determined in a cohort containing 173 cases of ICC patients. We found that CKAP4 was overexpressed in the majority of ICC cases and was significantly associated with tumor size, distant metastasis, lymph node metastasis, UICC and TNM stage features. Kaplan-Meier and Cox regression data indicated that CKAP4 was correlated with favorable clinical outcome and was an independent predictor for overall survival (HR, 0.646; 95% CI, 0.463-0.900 [p = 0.010]). Thus, CKAP4 may serve as a prognostic marker of ICC patients. (C) 2013 Elsevier Ireland Ltd. All rights reserved.