Progress in murine models of ruptured abdominal aortic aneurysm.
Progress in murine models of ruptured abdominal aortic aneurysm.
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DOI：
10.3389/fcvm.2022.950018
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发表时间：
2022
影响因子：
3.6
通讯作者：
Wang, Bowen
中科院分区：
文献类型：
--
作者：
Yin, Li;Kent, Eric William;Wang, Bowen
腹主动脉瘤（AAA）是一种在老年人群中普遍存在的主动脉局灶性扩张。AAA的进行性和不可预测的扩张可能导致动脉瘤破裂，这与约80%的死亡率相关。由于筛查工作的扩大和诊断工具的进步，越来越多的无症状AAA患者被发现，但没有治愈方法来阻止猖獗的主动脉扩张。阻碍有效AAA治疗发展的一个关键障碍是我们对其发病机制和破裂进展的细胞和分子基础的不完全理解。动物模型为AAA病理生理学提供了宝贵的机制见解。然而，没有单一的实验模型可以完全概括AAA背后的复杂生物学，不同的AAA诱导方法与不同的病程和破裂率相关。在这篇综述文章中，我们总结了已建立的小鼠AAA破裂模型，并讨论了各自的优点和效用。
Abdominal aortic aneurysm (AAA) is a focal dilation of the aorta that is prevalent in aged populations. The progressive and unpredictable expansion of AAA could result in aneurysmal rupture, which is associated with ~80% mortality. Due to the expanded screening efforts and progress in diagnostic tools, an ever-increasing amount of asymptomatic AAA patients are being identified yet without a cure to stop the rampant aortic expansion. A key barrier that hinders the development of effective AAA treatment is our incomplete understanding of the cellular and molecular basis of its pathogenesis and progression into rupture. Animal models provide invaluable mechanistic insights into AAA pathophysiology. However, there is no single experimental model that completely recapitulate the complex biology behind AAA, and different AAA-inducing methodologies are associated with distinct disease course and rupture rate. In this review article, we summarize the established murine models of ruptured AAA and discuss their respective strengths and utilities.
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影响因子：
4.2
作者：
Kugo H;Sukketsiri W;Tanaka H;Fujishima R;Moriyama T;Zaima N
通讯作者：
Zaima N
年龄相关的 Sirtuin 1 血管平滑肌减少与血管衰老和炎症与腹主动脉瘤有关
影响因子：
20.1
作者：
Chen HZ;Wang F;Gao P;Pei JF;Liu Y;Xu TT;Tang X;Fu WY;Lu J;Yan YF;Wang XM;Han L;Zhang ZQ;Zhang R;Zou MH;Liu DP
通讯作者：
Liu DP
影响因子：
15.9
作者：
Bruemmer, D;Collins, AR;Hsueh, WA
通讯作者：
Hsueh, WA
DOI：
10.1111/j.1749-6632.1999.tb07789.x
发表时间：
1999-01-01
期刊：
THE METABOLIC SYNDROME X
影响因子：
--
作者：
Daugherty, A;Cassis, L
通讯作者：
Cassis, L
DOI：
10.1161/atvbaha.120.315210
发表时间：
2021-04
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Ghaghada KB;Ren P;Devkota L;Starosolski Z;Zhang C;Vela D;Stupin IV;Tanifum EA;Annapragada AV;Shen YH;LeMaire SA
通讯作者：
LeMaire SA