Archimedes - A trial-validated model of diabetes
Archimedes - A trial-validated model of diabetes
复制标题
DOI：
10.2337/diacare.26.11.3093
复制
发表时间：
2003-11-01
期刊：
影响因子：
16.2
通讯作者：
Schlessinger, L
中科院分区：
文献类型：
--
作者：
Eddy, DM;Schlessinger, L
目的-建立一个数学模型的解剖学，病理生理学，测试，治疗和结果有关的糖尿病，可以应用到各种各样的临床和行政问题，并可以validated.RESEARCH设计和方法-我们使用了面向对象的方法，微分方程，和一个结构，我们称之为“功能”。“的细节和现实的水平是由临床医生认为重要的，需要区分临床相关变量，并在临床试验的进行中使用的详细程度。结果-该模型包括相关的器官系统，超过50个不断相互作用的生物变量，和主要症状，测试，治疗和结果。详细程度与一般医学教科书、病历、临床实践指南和临床试验设计中的详细程度相对应。该模型在时间上是连续的，并且连续地表示生物变量。正如配套文章中所证明的那样，这些方程可以模拟各种临床试验并以良好的准确性再现其结果。结论-可以建立一个数学模型，以高水平的生物学和临床细节复制糖尿病的病理生理学，并且可以通过模拟临床试验进行测试。
OBJECTIVE - To build a mathematical model of the anatomy, pathophysiology, tests, treatments, and outcomes pertaining to diabetes that could be applied to a wide variety of clinical and administrative problems and that could be validated.RESEARCH DESIGN AND METHODS - We used an object-oriented approach, differential equations, and a construct we call "features." The level of detail and realism was determined by what clinicians considered important, by the need to distinguish clinically relevant variables, and by the level of detail used in the conduct of clinical trials.RESULTS - The model includes the pertinent organ systems, more than 50 continuously interacting biological variables, and the major symptoms, tests, treatments, and outcomes. The level of detail corresponds to that found in general medical textbooks, patient charts, clinical practice guidelines, and designs of clinical trials. The model is continuous in time and represents biological variables continuously. As demonstrated in a companion article, the equations can simulate a variety of clinical trials and reproduce their results with good accuracy.CONCLUSIONS - It is possible to build a mathematical model that replicates the pathophysiology of diabetes at a high level of biological and clinical detail and that can be tested by simulating clinical trials.