Distinguishing features of endometrial pathology after exposure to the progesterone receptor modulator mifepristone.
Distinguishing features of endometrial pathology after exposure to the progesterone receptor modulator mifepristone.
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DOI：
10.1016/j.humpath.2010.11.003
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发表时间：
2011-07
期刊：
影响因子：
3.3
通讯作者：
Fiscella, Kevin
中科院分区：
文献类型：
--
作者：
Fiscella, Julietta;Bonfiglio, Thomas;Winters, Paul;Eisinger, Steven H.;Fiscella, Kevin
对使用孕酮受体调节剂（PRM）如米非司酮治疗妇科和其它病症的兴趣日益增加，但对PRM的兴趣受到药物对子宫内膜的作用的抑制。在这项研究中，我们检查了暴露于米非司酮治疗平滑肌瘤的妇女的子宫内膜，剂量为2.5毫克和5毫克，并将其与未暴露的子宫内膜进行比较。我们评估了这些功能的可靠性，通过比较协议之间的评级病理学家谁是盲目的对方的读数。我们通过比较组间特征的频率来评估暴露组和未暴露组之间的区别特征。我们发现，子宫内膜病理学经验丰富的病理学家可以可靠地评估关键特征。我们观察到几个特征（不同步的子宫内膜，大的充满液体的腺体和异常的血管），区分子宫内膜样品暴露于和未暴露于药物。这些发现表明，在涉及米非司酮和其他潜在PRM的研究中可以跟踪几个特征。
There is growing interest in use of progesterone receptor modulators (PRM) such as mifepristone for treatment of gynecological and other conditions, but interest in PRMs is dampened by effects of the agents on the endometrium. In this study, we examined the endometria of women exposed to mifepristone for treatment of leiomyomas in doses of 2.5 mg and 5 mg and compared them to unexposed endometria. We assessed the reliability of these features by comparing agreement in ratings between pathologists who were blinded to each other's readings. We assessed distinguishing features between exposed and unexposed groups by comparing frequency of features between groups. We found that key features could be reliably assessed by pathologists experienced in endometrial pathology. We observed several features (non synchronous endometrium, large fluid filled glands and abnormal blood vessels) that distinguished endometrial samples that were and were not exposed to the drug. These findings suggest several features that can be tracked during studies involving mifepristone and potentially other PRMs.
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影响因子：
7.2
作者：
Fiscella, Kevin;Eisinger, Steven H.;Guzick, David S.
通讯作者：
Guzick, David S.
影响因子：
2
作者：
HARRELL, FE;LEE, KL;ROSATI, RA
通讯作者：
ROSATI, RA
影响因子：
7.2
作者：
Eisinger, SH;Meldrum, S;Guzick, DS
通讯作者：
Guzick, DS
影响因子：
4.8
作者：
Girling, Jane E.;Lederman, Fiona L.;Rogers, Peter A. W.
通讯作者：
Rogers, Peter A. W.
影响因子：
22.4
作者：
HOLLAND, BS;COPENHAVER, MD
通讯作者：
COPENHAVER, MD