A Comprehensive Discussion in Vaginal Cancer Based on Mechanisms, Treatments, Risk Factors and Prevention.
A Comprehensive Discussion in Vaginal Cancer Based on Mechanisms, Treatments, Risk Factors and Prevention.
复制标题
DOI：
10.3389/fonc.2022.883805
复制
发表时间：
2022
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
阴道癌是一种罕见和不常见的疾病，很少讨论。虽然阴道癌传统上发生在绝经后的老年妇女中，但高危人乳头瘤病毒（HPV）诱导的癌症在年轻妇女中的发病率正在增加。宫颈癌细胞含有高危型人乳头瘤病毒（HPV）E6和E7蛋白，抑制HPV基因表达会导致细胞停止增殖并进入衰老。由于E6、E7蛋白促进了HPV的致癌机制，在此不仅调节P53、pRb的细胞降解，而且还促进细胞增殖，沿着E6蛋白靶向p53的降解，随后促进细胞凋亡，并抑制DNA修复，这对HPV的生命周期的延续是必不可少的。作为一种同时或异时性肿瘤，阴道癌经常与宫颈癌合并发现。目前还不确定是什么原因导致女性阴道器官癌。HPV 16型是女性阴道器官癌中最常见的HPV类型。由于癌症的罕见性，病例研究提供了大多数的病因学发现。许多研究结果表明，环子宫托，慢性阴道炎，性行为，产伤，肥胖，阴道化学品暴露和病毒都是危险因素。由于对该病的认识和发现不足，我们正试图通过现有的数据来寻找该病的发病机制。我们还讨论了不同的危险因素，在不同阶段的治疗，诊断和阴道癌的管理在这篇评论。
Vaginal cancer is a rare and uncommon disease that is rarely discussed. Although vaginal cancer traditionally occurs in older postmenopausal women, the incidence of high-risk human papillomavirus (HPV)-induced cancers is increasing in younger women. Cervical cancer cells contain high-risk human papillomavirus (HPV) E6 and E7 proteins and inhibiting HPV gene expression leads the cells to stop proliferating and enter senescence. As E6, and E7 protein promoted the carcinogenesis mechanism, and here not only regulate the cellular degradation of P53, and pRb but also enhances the cell proliferation along with E6 protein targets the p53 for breakdown and subsequently promote the apoptotic cell death, and DNA repair inhibition, that is indispensable to the continue the lifecycle of the HPV. As a synchronous or metachronous tumor, vaginal cancer is frequently found in combination with cervical cancer. It is uncertain what causes invasive female vaginal organ cancer. HPV type 16 is the most often isolated HPV type in female vaginal organ cancers. Due to cancer’s rarity, case studies have provided the majority of etiologic findings. Many findings demonstrate that ring pessaries, chronic vaginitis, sexual behavior, birth trauma, obesity, vaginal chemical exposure, and viruses are all risk factors. Because of insufficient understanding and disease findings, we are trying to find the disease’s mechanism with the available data. We also address different risk factors, therapy at various stages, diagnosis, and management of vaginal cancer in this review.
登录
查看更多内容
影响因子：
1.8
作者：
Capozzi VA;Monfardini L;Sozzi G;Armano G;Rosati A;Gueli Alletti S;Cosentino F;Ercoli A;Cianci S;Berretta R
通讯作者：
Berretta R
影响因子：
4.7
作者：
CHOO, YC;ANDERSON, DG
通讯作者：
ANDERSON, DG
影响因子：
6.2
作者：
SMART, CR
通讯作者：
SMART, CR
DOI：
10.1016/0360-3016(88)90110-1
发表时间：
1988-10-01
影响因子：
7
作者：
CURRAN, WJ;WHITTINGTON, R;FANNING, J
通讯作者：
FANNING, J
影响因子：
4.7
作者：
BALL, HG;BERMAN, ML
通讯作者：
BERMAN, ML