The effect of fish oil on physical aggression in schoolchildren - a randomized, double-blind, placebo-controlled trial
The effect of fish oil on physical aggression in schoolchildren - a randomized, double-blind, placebo-controlled trial
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DOI：
10.1016/j.jnutbio.2004.10.009
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发表时间：
2005-03-01
影响因子：
5.6
通讯作者：
Hamazaki, T
中科院分区：
文献类型：
--
作者：
Itomura, M;Hamazaki, K;Hamazaki, T
目的：这项研究的目的是调查鱼油补充剂是否影响日本学龄儿童的行为，随着时间的推移，侵略的变化作为主要endpoint.Design和科目：安慰剂对照的双盲研究与166名9-12岁的学龄儿童进行。鱼油组的受试者（n = 83）食用鱼油强化食品（面包、香肠和意大利面）。这些食物的提供量使得鱼油组中的每名受试者每周摄入3600 mg二十二碳六烯酸+840 mg二十碳五烯酸（EPA），持续3个月。其余（对照组，n = 83）服用对照补充剂。在研究开始和结束时，分别进行心理测试，以评估其攻击性。结果：采用儿童敌对-攻击性问卷评估的身体攻击性，女生显著增加（中位数：13至15，n = 42），未发生变化（13 - 13，n = 43），组间差异显著（P = 0.008），基线作为协变量。在同意采血的女孩中，身体攻击评分随时间的变化与红细胞中EPA/花生四烯酸的比值（Δ EPA/AA）显著相关（r = -.53，P = .01，n = 23）。相反，男孩的身体攻击性没有显著变化。通过图片挫折研究评估的对他人的攻击（外向）在对照组中没有变化（中位数：5 - 5），但在鱼油组中显著增加（4 - 5），具有显著的组间差异（P = .02），基线作为协变量。这些外移的变化可能部分解释为鱼油组（P = .02）的外移基线值显著低于对照组。49名儿童的Delta外向表达与Delta EPA/AA之间无显著相关性。由父母/监护人使用DSM-IV的注意力缺陷/多动障碍诊断标准评估的女孩冲动性在鱼油组中降低（1至0），与对照组（1至1）相比具有显著（P = .008）组间差异。在血样女孩中，Delta冲动和Delta EPA/AA之间没有显着相关性。在男性中，冲动减少，在两组中没有任何intergroup.Conclusion：有一种可能性，脂肪酸营养的变化可能会影响身体的侵略，特别是在女孩。(c)2005年爱思唯尔公司All rights reserved.
Objectives: The aim of the study was to investigate whether fish oil supplementation affected Japanese schoolchildren's behavior, with changes in aggression over time as the primary endpoint.Design and subjects: A placebo-controlled double-blind study with 166 schoolchildren 9-12 years of age was performed. The subjects of the fish oil group (n = 83) took fish oil-fortified foods (bread, sausage and spaghetti). These foods were provided in amounts such that each subject in the fish oil group had an intake of 3600 mg of docosahexaenoic acid + 840 mg of eicosapentaenoic acid (EPA)/week for 3 months. The rest (the controls, n = 83) took control supplements. At the start and end of the study, psychological tests were performed to assess their aggression.Results: Physical aggression assessed by Hostility-Aggression Questionnaire for Children in girls increased significantly (median: 13 to 15, n = 42) in the control group and did not change (13 to 13, n = 43) in the fish oil group with a significant intergroup difference (P = .008) with baseline as covariate. The changes in physical aggression scores over time and those of the ratio of EPA/arachidonic acid in RBC (Delta EPA/AA) were significantly correlated in girls who agreed to blood collection (r = -.53, P = .01, n = 23). On the contrary, there were no significant changes in physical aggression in boys. Aggression against others (extraggression) assessed by Picture Frustration Study did not change in the control group (median: 5 to 5) but increased significantly in the fish oil group (4 to 5) with a significant intergroup difference (P = .02) with baseline as covariate. These changes in extraggression might be explained partly by significantly lower baseline values of extraggression in the fish oil group (P = .02) than in the control group. There were no significant correlations between Delta extraggression and Delta EPA/AA in blood-sampled children (n = 49). Impulsivity of girls assessed by parents/guardians using the diagnostic criteria for attention deficit/hyperactivity disorder of DSM-IV was reduced in the fish oil group (1 to 0) with a significant (P = .008) intergroup difference from the control group (1 to 1). There were no significant correlations between Delta impulsivity and Delta EPA/AA in blood-sampled girls. In males, impulsivity reduced in both groups without any intergroup differences.Conclusion: There is a possibility that changes in fatty acid nutrition might affect physical aggression especially in girls. (c) 2005 Elsevier Inc. All rights reserved.