Galangin Induces Autophagy via Deacetylation of LC3 by SIRT1 in HepG2 Cells.
Galangin Induces Autophagy via Deacetylation of LC3 by SIRT1 in HepG2 Cells.
复制标题
高良姜素在 HepG2 细胞中通过 SIRT1 使 LC3 脱乙酰化来诱导自噬
DOI：
10.1038/srep30496
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发表时间：
2016-07-27
影响因子：
4.6
通讯作者：
Zhang H
中科院分区：
文献类型：
--
作者：
Li X;Wang Y;Xiong Y;Wu J;Ding H;Chen X;Lan L;Zhang H
Galangin suppresses proliferation and induces apoptosis and autophagy in hepatocellular carcinoma (HCC) cells, but the precise mechanism is not clear. In this study, we demonstrated that galangin induced autophagy, enhanced the binding of SIRT1-LC3 and reduced the acetylation of endogenous LC3 in HepG2 cells. But this autophagy was inhibited by inactivation of SIRT1 meanwhile, galangin failed to reduce the acetylation of endogenous LC3 after SIRT1 was knocked-down. Collectively, these findings demonstrate a new mechanism by which galangin induces autophagy via the deacetylation of endogenous LC3 by SIRT1.
