In vivo morphometry of the lamina cribrosa and its relation to visual field loss in glaucoma
In vivo morphometry of the lamina cribrosa and its relation to visual field loss in glaucoma
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DOI：
10.1080/02713689808951216
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发表时间：
1998-04-01
影响因子：
2
通讯作者：
Hitchings, RA
中科院分区：
文献类型：
--
作者：
Fontana, L;Bhandari, A;Hitchings, RA
目的.筛板被认为是青光眼视神经损伤的起源部位。本研究的目的是调查，在体内，筛板孔的青光眼患者的临床特征，并将其形态特征与他们的视野损失的程度。采用激光扫描检眼镜（SLO），在活体内观察了60例青光眼患者和15例正常人的筛板内表面图像。一个专门开发的图像处理技术，客观地评价孔形态，特别是关于他们的几何特征（圆度和伸长率）。采用Humphrey视野分析仪进行视觉功能评估。正常受试者显示近似圆形的椎板孔。在昏迷患者中，随着视野损失的增加，孔变得更长，更不圆（分别为p = 0.009和p < 0.001）。本文首次应用激光扫描检眼镜和图像处理新技术，对青光眼患者筛板与视野缺损程度的关系进行了活体研究。结果表明，筛板孔形态的差异与疾病的严重程度增加。这些变化可能代表了施加在层压板上的压缩力和剪切力的结果。
Purpose. The lamina cribrosa has been proposed as a site of origin of the optic nerve damage in glaucoma. The purpose of this study was to investigate, in vivo, the clinical features of the lamina cribrosa pores of glaucomatous patients and to relate their morphometric characteristics to the extent of their visual field loss.Methods. Images of the internal lamina cribrosa surface of 60 glaucomatous patients and 15 normal subjects were acquired, in vivo, using a scanning laser ophthalmoscope (SLO). A purposely developed technique of image processing was employed to objectively evaluate pore morphometry, with particular regard to their geometrical characteristics (circularity and elongation). Visual function was assessed by automated perimetry (Humphrey Field Analyser).Results. Normal subjects showed approximately round lamina pores. In glaucomatous patients, pores become more elongated and less circular with increasing field loss (p = 0.009 and p < 0.001, respectively).Conclusions. Scanning laser ophthalmoscopy and a new technique of image processing were employed, for the first time, to the investigation in vivo of the lamina cribrosa of glaucomatous patients, in relation to the extent of visual field loss. The results indicated differences in the lamina cribrosa pore morphometry associated with increasing severity of the disease. These changes may represent the result of compressing and shearing forces applied to the laminar plates.