Excess concordance of cancer incidence and lifestyles in married couples (Japan): survival analysis of paired rate data
Excess concordance of cancer incidence and lifestyles in married couples (Japan): survival analysis of paired rate data
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DOI：
10.1023/b:caco.0000036162.86921.09
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发表时间：
2004-08-01
影响因子：
2.3
通讯作者：
Nakachi, K
中科院分区：
文献类型：
--
作者：
Izumi, S;Imai, K;Nakachi, K
目的：开展一项基于人群的队列研究，以检验已婚夫妇癌症发病率与生活方式的一致性。方法：跟踪1986年9月1日至2000年6月30日日本崎玉县2601对40-84岁、无癌症且已完成流行病学调查问卷的社区已婚夫妇的癌症发病率。我们使用双变量生存分析方法，计算了年龄调整后的交叉比率：有配偶/没有配偶的比率，作为配对率数据的关联度。结果：夫妇的生活方式在饮食习惯方面的一致性较高，而在吸烟和饮酒习惯方面的一致性较低。在14年的随访中，发生了464例癌症病例(仅丈夫：279例，仅妻子：119例，双方：33对夫妇)。与丈夫未患癌症的妻子相比，丈夫罹患癌症的妻子自身罹患癌症的风险增加(CR：1.70，95%CI：1.12-2.58)。确诊时丈夫的平均年龄为68.2岁，妻子为66.0岁。结论：我们的数据表明，包括吸烟和饮酒习惯在内的共同生活方式与已婚夫妇癌症发病率的过度一致性有关。
Objective: A population-based cohort study was conducted to examine concordance of cancer incidence and lifestyle in married couples.Methods: Cancer incidence from I September 1986 to 30 June 2000 was followed for a baseline cohort of 2601 community-living married couples aged 40-84 years who were cancer-free and had completed an epidemiologic questionnaire in 1986 in Saitama, Japan. We computed age-adjusted cross-ratios: spouse-with/spouse-without rate ratios as a measure of association for paired rate data, using a bivariate survival analysis method.Results: Concordance of lifestyles for couples was high for dietary habits, and low for smoking and alcohol habits. During the 14 year follow-up, 464 cancer cases occurred (husbands only: 279, wives only: 119, both: 33 couples). Wives whose husbands developed cancer were at an increased risk of developing cancer themselves, compared with those whose husbands had not had cancer (CR: 1.70, 95 % CI: 1.12-2.58). Mean age at diagnosis was 68.2 years for husbands and 66.0 years for wives. And correlation of cancer incidence was further seen among couples who shared habits of smoking and/or drinking.Conclusions: Our data suggest that shared lifestyles including smoking and drinking habits are associated with an excess concordance of cancer incidence among married couples.