SOCIAL CONNECTIONS AND RISK FOR CANCER - PROSPECTIVE EVIDENCE FROM THE ALAMEDA COUNTY STUDY
SOCIAL CONNECTIONS AND RISK FOR CANCER - PROSPECTIVE EVIDENCE FROM THE ALAMEDA COUNTY STUDY
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DOI：
10.1080/08964289.1990.9934597
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发表时间：
1990-09-01
影响因子：
2.3
通讯作者：
KAPLAN, GA
中科院分区：
文献类型：
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作者：
REYNOLDS, P;KAPLAN, GA
对1965年居住在美国加利福尼亚州阿拉米达县的6848名成年人进行了为期17年的随访，研究了社会关系与癌症发病率、死亡率和预后之间的关系。相对危险度的估计来自Cox回归模型，调整了年龄、吸烟、基线身体健康、饮酒和调整后的家庭收入。被社会孤立的妇女死于各种癌症和与吸烟有关的癌症的风险显著增加。社会关系与男性癌症发病率或死亡率没有前瞻性联系，但社会关系少的男性癌症存活率明显较低。这些风险模式与不同癌症结果的生物学是一致的。他们还表明，社会孤立在男性和女性癌症中所起的作用不同。
The association between social connections and cancer incidence, mortality, and prognosis during 17 years of follow-up was examined in a population-based sample of 6,848 adults who lived in Alameda County, California (USA), in 1965. Estimates of relative hazards were derived from Cox regression modeling, adjusting for age, smoking, physical health at baseline, alcohol consumption, and adjusted household income. Women who were socially isolated were at significantly elevated risk of dying of cancer of all sites and of smoking-related cancers. Social connections were not prospectively associated with cancer incidence or mortality among men, but men with few social connections showed significantly poorer cancer survival rates. These patterns of risk are consistent with the biology of different cancer outcomes. They also suggest a different role for social isolation in cancer among men and women.