Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients
Tobacco smoke is related to Th17 generation with clinical implications for psoriasis patients
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DOI：
10.1111/j.1600-0625.2010.01224.x
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发表时间：
2011-04-01
影响因子：
3.6
通讯作者：
Morita, Akimichi
中科院分区：
文献类型：
--
作者：
Torii, Kan;Saito, Chiyo;Morita, Akimichi
环境因素通过辅助性T细胞17型（Th 17）激活导致自身免疫性疾病患病率增加。吸烟会增加牛皮癣的风险，但其机制尚不清楚。我们检测了27名健康志愿者（2.58 ± 0.80%）、33名吸烟者（3.55 ± 1.33%）和21名非吸烟者（3.10 ± 1.14%）银屑病患者外周血单个核细胞（PBMC）中循环Th 17在CD 3（+）细胞中的百分比，以阐明吸烟与银屑病的关系。吸烟者（19/33）比非吸烟者（6/21）具有高Th 17水平（Th 17/CD 3> 3.38%，健康志愿者的平均值± 1 SD）。烟草烟雾提取物（TSE，7 μ l/ml）在体外诱导中枢记忆T细胞产生Th 17。TSE可增加白细胞介素17和22的表达。这些发现表明烟草烟雾和IL-17和IL-22之间的关系，这加剧了银屑病。
Environmental factors contribute to the increased prevalence of autoimmune diseases via T helper type-17 cell (Th17) activation. Tobacco smoking increases the risk of psoriasis, but the mechanisms are not clear. We evaluated the percentage of circulating Th17 among CD3(+) cells in peripheral blood mononuclear cells (PBMC) obtained from 27 healthy volunteers (2.58 +/- 0.80%), 33 smoker (3.55 +/- 1.33%) and 21 non-smoker (3.10 +/- 1.14%) patients with psoriasis to elucidate the relation between smoking and psoriasis. More smokers (19/33) than non-smokers (6/21) had high Th17 levels (Th17/CD3 > 3.38%, mean + 1 SD of healthy volunteers). Tobacco smoke extract (TSE, 7 mu l/ml) induced Th17 generation from central memory T cells in vitro. TSE increased interleukin 17 and 22 expression. These findings demonstrate the relation between tobacco smoke and IL-17 and IL-22, which exacerbate psoriasis.