Transmission of Hepatitis C Virus by Anti‐HCV‐Negative Blood Transfusion: Case Report
Transmission of Hepatitis C Virus by Anti‐HCV‐Negative Blood Transfusion: Case Report
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通过抗 HCV 阴性输血传播丙型肝炎病毒：病例报告
DOI：
10.1111/j.1423-0410.1995.tb02546.x
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发表时间：
1995
期刊：
影响因子：
2.7
通讯作者：
P. Lelie
中科院分区：
文献类型：
--
作者：
H. Vrielink;C. Poel;H. Reesink;H. Zaaijer;P. Lelie
急性丙型肝炎输血后报告在受体3单位红细胞。输血后6周出现急性黄疸，诊断为HCV感染。经ELISA‐2检测为阴性的3例有牵连的捐献者的血清样本，用PCR和第三代抗体检测重新检测。其中一例疑似捐献PCR阳性，但抗HCV阴性。其他两名捐赠者的所有检测结果均为阴性。该献血者在相关捐献13周后被召回血库，并被发现ELISA‐3 + RIBA‐3阳性。捐献8个月后，供体仍呈PCR和RIBA‐3阳性，而受体变为PCR阴性，但仍呈抗HCV RIBA‐3阳性。该病例表明，在丙型肝炎病毒感染开放窗口期收集的献血者血液制品可将丙型肝炎病毒传播给接受者。
Acute posttransfusion hepatitis C was reported in a recipient of 3 units of red cells. The recipient became acutely icteric 6 weeks after transfusion, and HCV infection was diagnosed. Stored serum samples of the 3 implicated donations, which were negative with ELISA‐2, were retested by PCR and 3rd‐generation antibody tests. One implicated donation was PCR positive, but anti‐HCV negative. Both other donations were negative in all tests. The donor was recalled to the Blood Bank 13 weeks after the implicated donation and was found to be ELISA‐3 plus RIBA‐3 positive. Eight months after the implicated donation, the donor is still PCR and RIBA‐3 positive, whereas the recipient became PCR negative but remained anti‐HCV RIBA‐3 positive. The case shows that blood products from donors collected during the open window period of an HCV infection can transmit HCV to recipients.