Reduced fear expression after lesions of the ventral hippocampus
Reduced fear expression after lesions of the ventral hippocampus
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DOI：
10.1073/pnas.152112399
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发表时间：
2002-08-06
影响因子：
11.1
通讯作者：
Moser, MB
中科院分区：
文献类型：
--
作者：
Kjelstrup, KG;Tuvnes, FA;Moser, MB
海马体在一些基本的记忆操作中起着至关重要的作用，包括对情境信息的恐惧调节。我们发现海马体对于无条件的恐惧也是必要的，而且涉及的回路位于海马体的腹极。有选择性海马损伤的大鼠在高架+迷宫中无法避免张开双臂，并且在被限制在明亮的房间中时神经内分泌应激反应降低。海马体腹侧一半的损伤重现了这些影响，但海马体背侧四分之三或杏仁核的损伤却没有。腹侧损伤未能损害情境恐惧条件反射或空间导航，这表明腹侧海马可能特别影响某些类型的防御性恐惧相关行为。
The hippocampus has a critical role in several fundamental memory operations, including the conditioning of fear to contextual information. We show that the hippocampus is necessary also for unconditioned fear, and that the involved circuitry is at the ventral pole of the hippocampus. Rats with selective hippocampal lesions failed to avoid open arms in an elevated plus-maze and had decreased neuroendocrine stress responses during confinement to a brightly lit chamber. These effects were reproduced by lesions of the ventral half of the hippocampus, but not by damage to the dorsal three-quarters of the hippocampus or the amygdala. Ventral lesions failed to impair contextual fear conditioning or spatial navigation, suggesting that the ventral hippocampus may specifically influence some types of defensive fear-related behavior.