Cutaneous delayed-type hypersensitivity in patients with human immunodeficiency virus infection in Zaire.
Cutaneous delayed-type hypersensitivity in patients with human immunodeficiency virus infection in Zaire.
复制标题
扎伊尔人类免疫缺陷病毒感染患者皮肤迟发型超敏反应。
DOI：
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发表时间：
1989
期刊：
影响因子：
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通讯作者：
P. Piot
中科院分区：
文献类型：
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作者：
R. Colebunders;I. Lebughe;N. Nzila;D. Kalunga;H. Francis;R. Ryder;P. Piot
通过CMI-Multitest（梅里埃，里昂，法国）评估了扎伊尔金沙萨不同阶段人类免疫缺陷病毒（HIV）感染患者的皮肤迟发型超敏反应（DTH）反应。在48-72小时后读取皮肤试验。如果硬结大于2 mm，则认为对抗原的反应为阳性。皮肤无反应发生在HIV血清阳性患者中比健康对照组更常见（p <0.001），并且在晚期HIV疾病患者中最常见。结核菌素反应阳性的HIV血清阳性患者比无结核菌素反应阳性的HIV血清阳性患者更可能患有活动性结核病（TB）（p <0.001）。因此，结核病诊断应追求在HIV血清阳性患者结核菌素反应阳性。
Cutaneous delayed-type hypersensitivity (DTH) reactions were assessed by the CMI-Multitest (Merieux, Lyon, France) in patients with different stages of human immunodeficiency virus (HIV) infection in Kinshasa, Zaire. Skin tests were read after 48-72 h. A reaction to an antigen was considered positive if there was induration of greater than 2 mm. Cutaneous anergy occurred more often in HIV-seropositive patients than in healthy controls (p less than 0.001) and was most prevalent in patients with advanced HIV illness. HIV-seropositive patients with a positive tuberculin reaction were more likely to have active tuberculosis (TB) than HIV-seropositive patients without a positive tuberculin reaction (p less than 0.001). Therefore, a TB diagnosis should be pursued in HIV-seropositive patients with a positive tuberculin reaction.