APOE IMMUNOREACTIVITY AND MICROGLIAL CELLS IN ALZHEIMERS-DISEASE BRAIN
APOE IMMUNOREACTIVITY AND MICROGLIAL CELLS IN ALZHEIMERS-DISEASE BRAIN
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DOI：
10.1016/0304-3940(95)11763-m
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发表时间：
1995-07-28
影响因子：
2.5
通讯作者：
HAUW, JJ
中科院分区：
文献类型：
--
作者：
UCHIHARA, T;DUYCKAERTS, C;HAUW, JJ
用免疫双标记法研究了阿尔茨海默病（Alzheimer 'sdisease，AD）患者脑内载脂蛋白E（apoE）样免疫反应（IR）与淀粉样β肽（A β）、星形胶质细胞和小胶质细胞的空间关系。弥漫性apoE样IR见于A β弥漫性沉积物，在经典老年斑的核心明显增加。小胶质细胞，有时apoE免疫反应，经常在apoE样IR的地区，在那里他们往往成簇的核心apoE标记的老年斑。虽然在这些老年斑中可以看到星形胶质细胞突起，但细胞体总是与核心有一定距离。这些星形胶质细胞表达apoE样IR。小胶质细胞，其中一些apoE免疫反应，被认为是在apoE标记的老年斑的中心。这些数据表明，小胶质细胞发挥更显着的作用比星形胶质细胞在载脂蛋白E沉积在老年斑的阿尔茨海默病。
The spatial relationship of apolipoprotein E (apoE)-like immunoreactivity (IR) to amyloid beta-peptide (A beta), astrocytes and microglial cells in the brain of Alzheimer's disease was studied by double immunolabelling. Diffuse apoE-like IR was seen in A beta diffuse deposits, and markedly increased in the core of classic senile plaques. Microglial cells, sometimes immunoreactive for apoE, were frequent in areas of apoE-like IR, where they often grouped into clusters in the core of apoE-labelled senile plaques. Although astrocytic processes were seen within these senile plaques, the cell bodies were always at a distance from the core. None of these astrocytes expressed apoE-like IR. Microglial cells, some of them immunoreactive for apoE, were seen in the center of apoE-labelled senile plaques. These data suggest that microglial cells play a more significant role than astrocytes in apoE deposition in senile plaques of Alzheimer disease.