Oncological outcome after lung metastasis in patients presenting with localized chondrosarcoma at extremities: Tokai Musculoskeletal Oncology Consortium study.
Oncological outcome after lung metastasis in patients presenting with localized chondrosarcoma at extremities: Tokai Musculoskeletal Oncology Consortium study.
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DOI：
10.2147/ott.s107638
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发表时间：
2016
影响因子：
4
通讯作者：
Nishida Y
中科院分区：
文献类型：
--
作者：
Nakamura T;Matsumine A;Yamada S;Tsukushi S;Kawanami K;Ohno T;Katagiri H;Sugiura H;Yamada K;Yamada Y;Sudo A;Nishida Y
四肢软骨肉瘤患者肺转移后的肿瘤学转归尚未见报道。2000年6月至2013年6月，共有179例四肢软骨肉瘤患者在11家医院接受治疗。连续20名患者(11.2%)在四肢原发软骨肉瘤最初治疗后出现肺转移。我们调查了20例软骨肉瘤肺转移患者的肿瘤学转归。男14例，女6例，平均年龄49岁。从初次手术到出现肺转移的平均时间为34个月。平均随访期为48个月。我们从这项研究中排除了出现肺转移的患者。在最后的随访中，20名患者中有4名没有疾病证据，4名患者活着，12名患者死于疾病。肺转移后3年和5年生存率分别为51.5%和45.7%。单因素分析表明，肿瘤分级、肺外转移和肺转移治疗(包括转移瘤切除和射频消融术)是肿瘤学分析的重要预后因素。总之，这项研究评估了四肢软骨肉瘤合并肺转移患者的肿瘤学结果。虽然可能需要一项大规模的研究来证实这项研究的结果，但我们建议应该考虑切除转移瘤和/或射频消融术来提高转移后的存活率。
The oncological outcome after lung metastasis in patients with chondrosarcoma of the extremities has not been reported. Between June 2000 and June 2013, 179 patients with chondrosarcoma in the extremities were treated at eleven hospitals. Twenty consecutive patients (11.2%) developed lung metastases after initial treatment of primary chondrosarcoma in the extremities. We investigated the oncological outcome of 20 chondrosarcoma patients with lung metastasis. There were 14 males and six females with a mean age of 49 years. The mean duration between primary surgery and appearance of lung metastases was 34 months. The mean follow-up period was 48 months. We excluded patients with lung metastasis at the time of presentation from this study. At the final follow-up, four of 20 patients had no evidence of disease, four were alive with disease, and twelve had died of disease. The 3- and 5-year survival rates after lung metastasis were 51.5% and 45.7%, respectively. Tumor grade, extrapulmonary metastasis, and treatment for lung metastases including metastasectomy and radiofrequency ablation were identified by univariate analysis to be significant prognostic factors for oncological analysis. In conclusion, this study evaluated the oncological outcome in patients with chondrosarcoma of the extremities with lung metastasis. Although a large-scale study might be required to confirm the results of this study, we suggest that metastasectomy and/or radiofrequency ablation should be considered to improve postmetastatic survival.