The Membrane Phase Transition Gives Rise to Responsive Plasma Membrane Structure and Function
The Membrane Phase Transition Gives Rise to Responsive Plasma Membrane Structure and Function
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DOI：
10.1101/cshperspect.a041395
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发表时间：
2023-11-01
影响因子：
7.2
通讯作者：
Veatch，Sarah L.
中科院分区：
文献类型：
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作者：
Shelby，Sarah A.;Veatch，Sarah L.
几个小组最近报道了当膜蛋白通过配体结合或膜近端支架组装而组织时，细胞质膜中出现结构域的证据。这些领域招募和保留有利于液体有序相的成分，增加了几十年来的文献询问质膜组织和功能中膜相分离的贡献。在这里，我们建议，过去和现在的观察是一致的模型，其中膜具有高的组成的敏感性，所产生的热力学状态在一个单一的阶段，是接近的可溶解性相变。这种严格的框架自然允许组成波动形式的瞬态结构和诱导域形式的长寿命结构。以这种方式，质膜组成的生物学调节使得能够实现响应性组成景观，其促进和增强对质膜功能至关重要的细胞生物化学。
Several groups have recently reported evidence for the emergence of domains in cell plasma membranes when membrane proteins are organized by ligand binding or assembly of membrane proximal scaffolds. These domains recruit and retain components that favor the liquid-ordered phase, adding to a decades-old literature interrogating the contribution of membrane phase separation in plasma membrane organization and function. Here we propose that both past and present observations are consistent with a model in which membranes have a high compositional susceptibility, arising from their thermodynamic state in a single phase that is close to a miscibility phase transition. This rigorous framework naturally allows for both transient structure in the form of composition fluctuations and long-lived structure in the form of induced domains. In this way, the biological tuning of plasma membrane composition enables a responsive compositional landscape that facilitates and augments cellular biochemistry vital to plasma membrane functions.