Neurolipidomics: challenges and developments
Neurolipidomics: challenges and developments
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DOI：
10.2741/2258
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Han, Xianlin
中科院分区：
文献类型：
--
作者：
Han, Xianlin
脂质组学领域是系统生物学研究中发展最迅速的领域之一。考虑到神经系统中脂体(即神经脂体)的独特性和复杂性，神经脂体组学仍然具有相当大的挑战性，但也令人兴奋。近年来，随着基于MS的脂质组学的发展，特别是基于多维MS的鸟枪型脂质组学的快速发展，神经脂质组学取得了很大的进展。随着未来技术的加速发展，脂质组学能够渗透到单个脂质分子物种质量含量的低丰度和低丰度区域，可以预见，对神经元疾病状态至关重要的许多脂质代谢的生化机制将被越来越多地揭示。通过利用神经脂质组学可以揭示的神经元脂质组成和动力学更新的复杂性所固有的信息内容，可以收集对神经元可塑性和基因功能的实质性见解。通过神经脂质组学，可能会发现这些神经元疾病的标记物，这些标记物可以识别病理变化，并对疾病的发病、进展或严重程度进行诊断。因此，有了神经脂质组学，我们对神经系统复杂性的理解无疑会加快，因为许多谜团都被解开了。
The field of lipidomics is one of the most rapidly expanding areas of systems biology research. Considering the uniqueness and complexity of the lipidome in the nervous system ( i.e., neurolipidome), neurolipidomics remains quite challenging but exciting. With the recent development of mass spectrometry ( MS)-based lipidomics, particularly the rapid improvement of multi-dimensional MS-based shotgun lipidomics, much progress has been made in neurolipidomics. As the accelerated development of future technologies enables lipidomics penetrance into lower and lower abundance regions of mass contents of individual lipid molecular species, it can be anticipated that many biochemical mechanisms underlying lipid metabolism critical to neuronal disease states will be increasingly uncovered. Through exploiting the information content inherent in the complexity of neuronal lipid composition and kinetic turnover which can be revealed by neurolipidomics, substantial insights into neuronal plasticity and gene function can be gathered. Through neurolipidomics, the markers for these neuronal diseases which identify pathological alterations and are diagnostic of disease onset, progression or severity may potentially be discovered. Accordingly, with neurolipidomics, our understanding of the complexities of the nervous system will be undoubtedly accelerated, as many mysteries are resolved.