A band-like balding disorder
A band-like balding disorder
复制标题
带状秃发症
DOI：
10.1016/s0140-6736(13)60804-1
复制
发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Kern JS
中科院分区：
文献类型：
--
作者：
Kiritsi D;Diaz-Cascajo C;Hoffmann R;Happle R;Jakob T;Kern JS
一名 34 岁白人男子的额头上出现了一块红斑、非鳞屑性硬化斑块。在大约一年的时间里，它延伸到头皮上，导致线性非疤痕性脱发，似乎遵循 Blaschko 的线条（图）。局部糖皮质激素的初始治疗失败，并进行了皮肤活检。组织病理学检查显示表皮正常，真皮内粘蛋白堆积，淋巴细胞性脂膜炎（图）。诊断为线状皮肤深部狼疮。实验室检查除抗核抗体阳性（1：200）和 C3d 补体轻微升高外均正常。在口服羟氯喹治疗下，该疾病在 12 周内得到缓解，随后毛发完全再生。维持治疗1年无复发。面部和头皮是皮肤性深部红斑狼疮的好发部位。这可能导致类似斑秃的临床表现或非疤痕性线性脱发，迄今为止主要在东亚人中报道。
An erythematous, non-scaling indurated plaque appeared on the forehead of a 34-year-old white man. Over a period of approxinately 1 year, it extended onto the scalp, resulting in a linear non-scarring alopecia, seemingly following the lines of Blaschko (figure). Initial therapy with topical glucocorticoids failed, and a skin biopsy was taken. Histopathological examination showed a normal epidermis, accumulation of mucin in the dermis, and lymphocytic panniculitis (figure). Linear cutaneous lupus profundus was diagnosed. Laboratory tests were normal, apart from positive antinuclear anti bodies (1: 200) and slightly increased C3d complement. Under oral hydroxychloroquine therapy the disorder resolved within 12 weeks, followed by complete regrowth of hair. No relapse occurred during 1 year of maintenance treatment. The face and scalp are predilection sites of cutaneous lupus erythematosus profundus. This can result in an alopecia areata-like clinical picture or nonscarring linear alopecia, which has thus far mainly been reported in east Asians.