Diffusion tensor imaging and optimized fiber tracking in glioma patients: Histopathologic evaluation of tumor-invaded white matter structures
Diffusion tensor imaging and optimized fiber tracking in glioma patients: Histopathologic evaluation of tumor-invaded white matter structures
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DOI：
10.1016/j.neuroimage.2006.08.051
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发表时间：
2007-02-01
期刊：
影响因子：
5.7
通讯作者：
Ganslandt, Oliver
中科院分区：
文献类型：
--
作者：
Stadlbauer, Andreas;Nimsky, Christopher;Ganslandt, Oliver
纤维跟踪越来越多地用于计划和指导脑功能重要区域附近的颅内肿瘤的神经外科手术。然而，缺乏关于跟踪相对于实际病理解剖情况的可靠性的有效数据。我们回顾性地将基于磁共振（MR）DT成像的纤维追踪与25例WHO II级和III级胶质瘤患者的组织病理学数据相关联。使用连续跟踪纤维分配（FACT）方法进行纤维跟踪，以研究病变周围边缘区域中白色物质束的完整性。当分数各向异性（FA）阈值=0.1、0.15、0.2、0.25和0.3或遇到束转向角> 60度时，停止跟踪程序。在9例患者中，我们能够使用0.15和0.2的FA阈值重建活检部位（2-32%肿瘤浸润）的脑纤维束，但不能使用0.25或0.3的阈值。神经学结局表明，功能完整的脑纤维束的潜在肿瘤细胞浸润范围为2- 8%。这些发现可能有助于规划在功能区附近的胶质瘤的治疗方法。(c)2006年爱思唯尔公司All rights reserved.
Fiber tracking is increasingly used to plan and guide neurosurgical procedures of intracranial tumors in the vicinity of functionally important areas of the brain. However, valid data concerning the reliability of tracking with respect to the actual pathoanatomical situation are lacking. We retrospectively correlated fiber tracking based on magnetic resonance (MR) DT imaging with the histopathological data of 25 patients with WHO grade II and III gliomas. Fiber tracking using the Fiber Assignment by Continuous Tracking (FACT) method was performed to investigate the integrity of white matter tracts in the surrounding border zone of the lesions. The tracking procedure was stopped when fractional anisotropy (FA) thresholds=0.1, 0.15, 0.2, 0.25, and 0.3, or a tract turning angle > 60 degrees were encountered. In 9 patients we were able to reconstruct brain fiber tracts at biopsy loci (2-32% tumor infiltration) using an FA threshold of 0.15 and 0.2, but not for a threshold of 0.25 or 0.3. The neurological outcome demonstrated potential tumor cell infiltration of functionally intact brain fiber tracts in the range of 2-8%. These findings may be useful in planning therapeutic approaches to gliomas in the vicinity of eloquent brain regions. (c) 2006 Elsevier Inc. All rights reserved.