Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
Anthelmintic Flubendazole and Its Potential Use in Anticancer Therapy.
复制标题
DOI：
10.14712/18059694.2017.44
复制
发表时间：
2017-01-01
影响因子：
--
通讯作者：
Rudolf, Emil
中科院分区：
文献类型：
--
作者：
Canova, Kristyna;Rozkydalova, Lucie;Rudolf, Emil
氟苯达唑是一种广泛使用的驱虫药，属于苯并咪唑类药物。氟苯达唑的分子作用机制是基于其与微管蛋白的特异性结合，导致微管结构和功能的破坏，并干扰蠕虫吸收组织中微管介导的分泌囊泡的运输。苯并咪唑衍生物的微管破坏特性最近引起了人们对这些化合物作为可能的抗癌药物的兴趣。在这篇小综述中，讨论了氟苯达唑对选定的人类恶性细胞（包括骨髓瘤、白血病、神经母细胞瘤、乳腺癌、结直肠癌和黑色素瘤）的作用，以及其药代动力学、代谢和毒性的基本数据。
Flubendazole is a widely used anthelmintic drug belonging to benzimidazole group. The molecular mechanism of action of flubendazole is based on its specific binding to tubulin, which results in disruption of microtubule structure and function, and in the interference with the microtubule-mediated transport of secretory vesicles in absorptive tissues of helminths. The microtubule-disrupting properties of benzimidazole derivatives raised recently interest in these compounds as possible anti-cancer agents. In this minireview flubendazole effects towards selected human malignant cells including myeloma, leukemia, neuroblastoma, breast cancer, colorectal cancer and melanoma are discussed along with basic data on its pharmacokinetics, metabolism and toxicity.